Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 1/20 | 0.51 |
| ▸ | HTR7 | P34969 | 1/20 | 0.44 |
| ▸ | HTR2A | P28223 | 2/20 | 0.40 |
| ▸ | HRH1 | P35367 | 1/20 | 0.40 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.38 |
| ▸ | MAOA | P21397 | 1/20 | 0.35 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.33 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.33 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.33 |
| ▸ | PNMT | P11086 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6666869 | 0.95 | HTR6 (0.50) | HTR6HTR7HTR2AHRH1SIGMAR1 | |
| SCHEMBL3862943 | 0.89 | HTR6 (0.59) | HTR6HTR7HTR2AHRH1SIGMAR1 | |
| SCHEMBL31547775 | 0.89 | HTR6 (0.59) | HTR6HTR7HTR2AHRH1SIGMAR1 | |
| SCHEMBL3868123 | 0.88 | HTR6 (0.53) | HTR6HTR7SIGMAR1MAOA | |
| SCHEMBL3874874 | 0.88 | HTR6 (0.53) | HTR6HTR7SIGMAR1MAOA | |
| SCHEMBL31121639 | 0.84 | HTR6 (0.56) | HTR6HTR7SIGMAR1MAOA | |
| SCHEMBL2338975 | 0.84 | HTR6 (0.56) | HTR6HTR7SIGMAR1MAOA | |
| SCHEMBL11623964 | 0.81 | HTR6 (0.47) | HTR6HTR7SIGMAR1 | |
| SCHEMBL16340383 | 0.81 | HTR6 (0.47) | HTR6HTR7SIGMAR1PNMT | |
| SCHEMBL20430497 | 0.81 | HTR6 (0.47) | HTR6HTR7SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1359916-A4 | IMIDAZOLYL DERIVATIVES AS CORTICOTROPIN RELEASING FACTOR INHIBITORS | BRISTOL MYERS SQUIBB CO (US) | 2004-04-07 | — | — | EP | disclosed |
| EP-1359916-A1 | IMIDAZOLYL DERIVATIVES AS CORTICOTROPIN RELEASING FACTOR INHIBITORS | Bristol-Myers Squibb Company (US) | 2003-11-12 | — | — | EP | disclosed |
| WO-2002058704-A1 | IMIDAZOLYL DERIVATIVES AS CORTICOTROPIN RELEASING FACTOR INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2002-08-01 | — | — | WO | disclosed |
| US-4127578-A | Diene intermediates for indantetrols | E. R. SQUIBB & SONS, INC. (US) | 1978-11-28 | — | — | US | disclosed |
| US-4092318-A | HYPOTENSIVES | E. R. SQUIBB & SONS, INC. (US) | 1978-05-30 | — | — | US | disclosed |
| US-4044040-A | HYPERTENSIVE AGENTS | E. R. SQUIBB & SONS, INC. (US) | 1977-08-23 | — | — | US | disclosed |