Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 5/20 | 0.53 |
| ▸ | RAB9A | P51151 | 4/20 | 0.53 |
| ▸ | TP53 | P04637 | 2/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.53 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.53 |
| ▸ | HRH3 | Q9Y5N1 | 6/20 | 0.50 |
| ▸ | MMP1 | P03956 | 1/20 | 0.47 |
| ▸ | MMP9 | P14780 | 1/20 | 0.47 |
| ▸ | MMP13 | P45452 | 1/20 | 0.47 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.46 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | FAAH | O00519 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11625071 | 0.87 | OPRL1 (0.58) | KMT2AMEN1ALDH1A1OPRL1POLB | |
| Hydrochloric Acid SCHEMBL11626817 | 0.86 | POLB (0.59) | KMT2AMEN1ALDH1A1OPRL1POLB | |
| SCHEMBL11627662 | 0.81 | SIGMAR1 (0.50) | KMT2AMEN1OPRL1POLB | |
| SCHEMBL5258408 | 0.79 | OPRL1 (0.71) | NPC1RAB9ATP53KMT2AKDM4E | |
| SCHEMBL325247 | 0.79 | NPC1 (0.53) | NPC1RAB9ATP53KMT2AKDM4E | |
| SCHEMBL11625286 | 0.78 | GRM2 (0.47) | NPC1RAB9ATP53KMT2AKDM4E | |
| SCHEMBL4536162 | 0.76 | LMNA (0.53) | RAB9ASMN1; SMN2MMP13MAPTGAA | |
| SCHEMBL1143656 | 0.76 | NPC1 (0.85) | NPC1RAB9ATP53KMT2AKDM4E | |
| Hydrochloric Acid SCHEMBL10955539 | 0.75 | POLB (0.49) | KMT2AKDM4EMEN1ALDH1A1HTT | |
| SCHEMBL10881522 | 0.74 | CCR3 (0.49) | MMP1MMP9MMP13ADAM17OPRL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4092330-A | 7,7-DIPHENYL-HEXAHYDRO-1,4-OXAZEPINES, ANTIDEPRESSANTS | CIBA-GEIGY CORPORATION (US) | 1978-05-30 | — | — | US | disclosed |
| US-4010166-A | 1,4-Oxazepines | CIBA-GEIGY CORPORATION (US) | 1977-03-01 | — | — | US | disclosed |