Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.52 |
| ▸ | GBA1 | P04062 | 1/20 | 0.47 |
| ▸ | HTR2A | P28223 | 4/20 | 0.43 |
| ▸ | HRH1 | P35367 | 2/20 | 0.43 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.41 |
| ▸ | PLAU | P00749 | 1/20 | 0.41 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.39 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.39 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.39 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.39 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.39 |
| ▸ | ANPEP | P15144 | 2/20 | 0.37 |
| ▸ | RET | P07949 | 1/20 | 0.36 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11627072 | 0.78 | SIGMAR1 (0.52) | SIGMAR1CHRM1 | |
| SCHEMBL5967983 | 0.77 | HTR6 (0.50) | SIGMAR1HTR2AHRH1RET | |
| Hydrochloric Acid SCHEMBL8300848 | 0.77 | IDO1 (0.56) | SIGMAR1GBA1HTR2AHRH1CYP19A1 | |
| SCHEMBL2840630 | 0.76 | PLAU (0.50) | SIGMAR1HTR2AHRH1PLAUCYP19A1 | |
| SCHEMBL5712654 | 0.76 | PLAU (0.52) | SIGMAR1GBA1HTR2AHRH1PLAU | |
| SCHEMBL29992701 | 0.76 | PLAU (0.52) | SIGMAR1GBA1HTR2AHRH1PLAU | |
| SCHEMBL6783014 | 0.75 | HTR2A (0.42) | HTR2AHRH1CHRM1CHRM2CHRM4 | |
| SCHEMBL131735 | 0.75 | SIGMAR1 (0.76) | SIGMAR1 | |
| SCHEMBL129839 | 0.75 | — | — | |
| SCHEMBL4803094 | 0.74 | GBA1 (0.57) | SIGMAR1GBA1CHRM1PLAUCYP19A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4127578-A | Diene intermediates for indantetrols | E. R. SQUIBB & SONS, INC. (US) | 1978-11-28 | — | — | US | disclosed |
| US-4092318-A | HYPOTENSIVES | E. R. SQUIBB & SONS, INC. (US) | 1978-05-30 | — | — | US | disclosed |
| US-4044040-A | HYPERTENSIVE AGENTS | E. R. SQUIBB & SONS, INC. (US) | 1977-08-23 | — | — | US | disclosed |