Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.66 |
| ▸ | PDE3B | Q13370 | 15/20 | 0.62 |
| ▸ | PDE3A | Q14432 | 15/20 | 0.62 |
| ▸ | TNNC1 | P63316 | 1/20 | 0.62 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.58 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.58 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.58 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.58 |
| ▸ | TSHR | P16473 | 1/20 | 0.58 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.58 |
| ▸ | LMNA | P02545 | 1/20 | 0.58 |
| ▸ | BLM | P54132 | 1/20 | 0.58 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.58 |
| ▸ | PDE4A | P27815 | 3/20 | 0.56 |
| ▸ | PDE4B | Q07343 | 3/20 | 0.56 |
| ▸ | PDE4C | Q08493 | 3/20 | 0.56 |
| ▸ | PDE4D | Q08499 | 3/20 | 0.56 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10353457 | 0.87 | PDE3B (0.71) | PDE3BPDE3ATNNC1PDE4APDE4B | |
| SCHEMBL5679278 | 0.87 | PDE3B (0.55) | GPR119PDE3BPDE3ATNNC1KDM4E | |
| SCHEMBL5679287 | 0.87 | PDE3B (0.55) | GPR119PDE3BPDE3ATNNC1KDM4E | |
| SCHEMBL11171307 | 0.86 | GPR119 (0.53) | GPR119PDE3BPDE3ATNNC1KDM4E | |
| SCHEMBL11626983 | 0.83 | GPR119 (0.72) | GPR119PDE3BPDE3ATNNC1PDE4A | |
| SCHEMBL5679283 | 0.83 | PDE3B (0.62) | GPR119PDE3BPDE3ATNNC1KDM4E | |
| SCHEMBL11171310 | 0.82 | PDE3B (0.61) | GPR119PDE3BPDE3ATNNC1KDM4E | |
| SCHEMBL11159048 | 0.82 | PDE3B (0.63) | GPR119PDE3BPDE3ATNNC1KDM4E | |
| SCHEMBL8342501 | 0.81 | PDE3B (0.64) | PDE3BPDE3ATNNC1PDE4APDE4B | |
| SCHEMBL22317993 | 0.81 | PDE3B (0.64) | PDE3BPDE3ATNNC1PDE4APDE4B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4117130-A | 6-PHENYL-1,2,4-TRIAZOLO(4,3-B)PYRIDAZINES | AMERICAN CYANAMID COMPANY (US) | 1978-09-26 | — | — | US | disclosed |
| US-4112095-A | 6-Phenyl-1,2,4-triazolo[4,3-b]pyridazine hypotensive agents | AMERICAN CYANAMID COMPANY (US) | 1978-09-05 | — | — | US | disclosed |
| US-4092311-A | Hypotensive alkyl-3-[6-(aryl)-3-pyridazinyl]-carbazates | AMERICAN CYANAMID COMPANY (US) | 1978-05-30 | — | — | US | disclosed |