SCHEMBL11625643

SCHEMBL11625643

O=C(O)c1cccn1/C=C/c1ccccc1

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HDAC1 Q13547 3/20 0.42
LMNA P02545 3/20 0.42
MAPT P10636 3/20 0.42
RECQL P46063 3/20 0.42
HDAC3 O15379 2/20 0.42
HDAC4 P56524 2/20 0.42
HDAC2 Q92769 2/20 0.42
HDAC8 Q9BY41 2/20 0.42
HDAC6 Q9UBN7 2/20 0.42
PLIN1 O60240 2/20 0.42
PLIN5 Q00G26 2/20 0.42
ABHD5 Q8WTS1 2/20 0.42
ALDH1A1 P00352 2/20 0.42
CYP1A2 P05177 2/20 0.42
TNKS O95271 1/20 0.42
HCAR2 Q8TDS4 1/20 0.42
HDAC7 Q8WUI4 1/20 0.42
HDAC10 Q969S8 1/20 0.42
HDAC11 Q96DB2 1/20 0.42
TNKS2 Q9H2K2 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11741711 1.00 HDAC1 (0.42) HDAC1LMNAMAPTRECQLHDAC3
SCHEMBL11625650 1.00 HDAC1 (0.42) HDAC1LMNAMAPTRECQLHDAC3
Trifluoroacetic Acid SCHEMBL11736488 0.91 CYP2C19 (0.36) HDAC1LMNAMAPTRECQLHDAC3
Trifluoroacetic Acid SCHEMBL11736509 0.91 CYP2C19 (0.36) HDAC1LMNAMAPTRECQLHDAC3
Trifluoroacetic Acid SCHEMBL11736493 0.91 CYP2C19 (0.36) HDAC1LMNAMAPTRECQLHDAC3
SCHEMBL11736500 0.77 MAOB (0.33) HDAC1LMNAMAPTRECQLHDAC3
SCHEMBL4230925 0.75 TDP1 (0.43) HDAC1LMNAMAPTRECQLHDAC4
SCHEMBL27831906 0.75 ALDH1A1 (0.44) HDAC1LMNAMAPTRECQLHDAC3
SCHEMBL25364773 0.73 MAOB (0.41) HDAC1LMNAMAPTRECQLHDAC3
SCHEMBL1664457 0.73 POLB (0.42) HDAC1LMNAMAPTRECQLHDAC4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4112112-A Pyrrolo[2,1-b] [3]benzazepines useful for producing a skeletal muscle relaxing or tranquilizing effect MERCK & CO., INC. (US) 1978-09-05 US disclosed
US-4075225-A Pyrrolo[2,1-b][3]benzazepines MERCK & CO., INC. (US) 1978-02-21 US disclosed
US-4056536-A CHEMICAL INTERMEDIATES MERCK & CO., INC. (US) 1977-11-01 US disclosed
US-4056536-A CHEMICAL INTERMEDIATES MERCK & CO., INC. (US) 1977-11-01 US disclosed