Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | HRH1 | P35367 | 4/20 | 0.42 |
| ▸ | DRD3 | P35462 | 3/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.42 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.42 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.42 |
| ▸ | HRH2 | P25021 | 2/20 | 0.42 |
| ▸ | HTR2A | P28223 | 2/20 | 0.42 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.42 |
| ▸ | HTR2B | P41595 | 2/20 | 0.42 |
| ▸ | USP2 | O75604 | 2/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.42 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.42 |
| ▸ | DRD2 | P14416 | 1/20 | 0.42 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.42 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11627583 | 0.93 | HRH3 (0.53) | KDM4EHRH3MAPTHRH1DRD3 | |
| SCHEMBL11623365 | 0.92 | HRH3 (0.49) | KDM4EHRH3MAPTHRH1DRD3 | |
| SCHEMBL11627527 | 0.85 | HRH3 (0.45) | POLBHRH3HRH1DRD3KCNH2 | |
| SCHEMBL10503605 | 0.83 | KDM4E (0.48) | KDM4EHRH3HRH1DRD3KCNH2 | |
| SCHEMBL11624816 | 0.78 | HRH3 (0.55) | KDM4EPOLBHRH3HRH1DRD3 | |
| SCHEMBL11625094 | 0.77 | HRH3 (0.51) | KDM4EPOLBHRH3HRH1DRD3 | |
| SCHEMBL11627158 | 0.77 | CYP2D6 (0.54) | HRH3CYP2D6SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL11623216 | 0.75 | CYP3A4 (0.48) | HRH3HTR2ACYP3A4CHRM1MC4R | |
| SCHEMBL13949605 | 0.74 | DRD3 (0.71) | KDM4ESMN1; SMN2HRH3HRH1DRD3 | |
| SCHEMBL11968882 | 0.72 | HRH3 (0.56) | POLBHRH3MAPTDRD3KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4125612-A | N-1-(p-Biphenylalkyl)piperazines and their use as anti-inflammatory agents | SCHERING CORPORATION (US) | 1978-11-14 | — | — | US | disclosed |