SCHEMBL1162655

SCHEMBL1162655

O=C1Nc2ccccc2/C1=C/c1ccc[nH]1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PDPK1 O15530 10/20 1.00
TLK2 Q86UE8 6/20 1.00
PDGFRB P09619 5/20 1.00
KDR P35968 4/20 1.00
RET P07949 4/20 1.00
FLT3 P36888 3/20 1.00
JAK3 P52333 3/20 1.00
FLT1 P17948 2/20 1.00
ALK Q9UM73 2/20 1.00
CDK5 Q00535 2/20 1.00
AURKB Q96GD4 2/20 1.00
SYK P43405 1/20 1.00
ATM Q13315 1/20 1.00
CHEK1 O14757 1/20 1.00
AURKA O14965 1/20 1.00
DAPK3 O43293 1/20 1.00
PRKD3 O94806 1/20 1.00
MAP4K4 O95819 1/20 1.00
NTRK1 P04629 1/20 1.00
LCK P06239 1/20 1.00

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30898303 1.00 PDPK1 (1.00) PDPK1TLK2PDGFRBKDRRET
SCHEMBL1162656 1.00 PDPK1 (1.00) PDPK1TLK2PDGFRBKDRRET
SCHEMBL30898301 1.00 PDPK1 (1.00) PDPK1TLK2PDGFRBKDRRET
SCHEMBL29385385 1.00 PDPK1 (1.00) PDPK1TLK2PDGFRBKDRRET
SCHEMBL13038796 1.00 PDPK1 (1.00) PDPK1TLK2PDGFRBKDRRET
SCHEMBL32676559 0.85 PDPK1 (0.74) PDPK1TLK2PDGFRBKDRRET
SCHEMBL32676535 0.85 PDPK1 (0.74) PDPK1TLK2PDGFRBKDRRET
SCHEMBL32676572 0.85 PDPK1 (0.74) PDPK1TLK2PDGFRBKDRRET
SCHEMBL7819649 0.82 PDPK1 (0.68) PDPK1TLK2PDGFRBKDRRET
SCHEMBL7819646 0.82 PDPK1 (0.68) PDPK1TLK2PDGFRBKDRRET

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 161 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1641435-A2 RATE CONTROLLED RELEASE OF A PHARMACEUTICAL AGENT IN A BIODEGRADABLE DEVICE BAUSCH & LOMB INCORPORATED (US) 2006-04-05 EP claimed
US-20050031669-A1 Rate controlled release of a pharmaceutical agent in a biodegradable device BAUSCH & LOMB INCORPORATED (US) 2005-02-10 US claimed
WO-2004112748-A2 RATE CONTROLLED RELEASE OF A PHARMACEUTICAL AGENT IN A BIODEGRADABLE DEVICE BAUSCH & LOMB INCORPORATED (US) 2004-12-29 WO claimed
US-20040253293-A1 Rate controlled release of a pharmaceutical agent in a biodegradable device BAUSCH & LOMB INCORPORATED 2004-12-16 US claimed
EP-0769947-B1 INDOLINONE COMPOUNDS FOR THE TREATMENT OF DISEASE SUGEN INC (US) 2001-05-02 EP claimed
EP-0769947-A4 INDOLINONE COMPOUNDS FOR THE TREATMENT OF DISEASE SUGEN INC (US) 1998-09-30 EP claimed
US-5792783-A CAPABLE OF MODULATING TYROSINE KINASE SIGNAL TRANSDUCTION IN ORDER TO REGULATE, MODULATE AND/OR INHIBIT ABNORMAL CELL PROLIFERATION SUGEN, INC. (US) 1998-08-11 US claimed
EP-0769947-A1 INDOLINONE COMPOUNDS FOR THE TREATMENT OF DISEASE Sugen, Inc. (US) 1997-05-02 EP claimed
WO-1996040116-A1 INDOLINONE COMPOUNDS FOR THE TREATMENT OF DISEASE SUGEN, INC. (US) 1996-12-19 WO claimed
EP-4662319-A2 PERSONALIZED CRISPR PROFILING FOR CANCER Integrate Bioscience LLC (US) 2025-12-17 EP disclosed
WO-2024168301-A2 PERSONALIZED CRISPR PROFILING FOR CANCER FUNCTION ONCOLOGY, INC. (US) 2024-08-15 WO disclosed
US-20240156825-A1 USE OF SELECTIVE VEGFR2 AND FGFR1 INHIBITORS FOUNTAIN THERAPEUTICS INC (US) 2024-05-16 US disclosed
US-20190083495-A1 Methods Of Preventing Or Reducing A Fibrotic Response Using CSF1R Inhibitors MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) 2019-03-21 US disclosed
EP-2635568-B1 PROCESSES FOR THE PREPARATION OF 3-(PYRROL-2-YL)METHYLENE)-2-PYRROLONES USING 2-SILYLOXY-PYRROLES SCINOPHARM (KUNSHAN) BIOCHEMICAL TECH CO LTD (CN) 2017-08-16 EP disclosed
US-5886020-A MODULATING TYROSINE KINASE SIGNAL TRANSDUCTION IN ORDER TO REGULATE OR INHIBIT ABNORMAL CELL PROLIFERATION SUGEN, INC. (US) 1999-03-23 US disclosed
US-5883113-A TYROSINE KINASE INHIBITORS; ANTIPROLIFERATIVE AND ANTICARCINOGENIC AGENTS; DIABETES, ARTHRITIS, RESTENOSIS, ATHEROSCLEROSIS SUGEN, INC. (US) 1999-03-16 US disclosed
US-5883116-A ANTITUMOR AGENTS AND ENZYME INHIBITORS SUGEN, INC. (US) 1999-03-16 US disclosed
US-5880141-A CONTROLLING, MODULATING AND INHIBITING TYROSINE KINASE SIGNAL TRANSDUCTION SUGEN, INC. (US) 1999-03-09 US disclosed
US-5834504-A MODULATING, INHIBITING ABNORMAL CELL PROLIFERATION; ENZYME INHIBITION SUGEN, INC. (US) 1998-11-10 US disclosed
US-5792783-A CAPABLE OF MODULATING TYROSINE KINASE SIGNAL TRANSDUCTION IN ORDER TO REGULATE, MODULATE AND/OR INHIBIT ABNORMAL CELL PROLIFERATION SUGEN, INC. (US) 1998-08-11 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20190083495-A1 Methods Of Preventing Or Reducing A Fibrotic Response Using CSF1R Inhibitors CSF1R, CSF3R, CD209 PDPK1 3443/4885TLK2 4160/4885PDGFRB 31/4885
US-20240156825-A1 USE OF SELECTIVE VEGFR2 AND FGFR1 INHIBITORS FGFR1, FRS2, FGFR2 PDPK1 58/4885TLK2 1011/4885PDGFRB 19/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.