Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NLRP3 | Q96P20 | 8/20 | 0.47 |
| ▸ | KCNJ11 | Q14654 | 10/20 | 0.39 |
| ▸ | ABCC9 | O60706 | 5/20 | 0.39 |
| ▸ | ABCC8 | Q09428 | 5/20 | 0.39 |
| ▸ | KCNJ8 | Q15842 | 5/20 | 0.39 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.35 |
| ▸ | RORC | P51449 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11628632 | 0.90 | NLRP3 (0.45) | NLRP3KCNJ11 | |
| SCHEMBL11625397 | 0.84 | NLRP3 (0.40) | NLRP3KCNJ11ABCC9ABCC8KCNJ8 | |
| SCHEMBL11624493 | 0.78 | KCNJ11 (0.38) | KCNJ11ABCC9ABCC8KCNJ8 | |
| SCHEMBL11624098 | 0.76 | NLRP3 (0.39) | NLRP3 | |
| SCHEMBL11625273 | 0.73 | NLRP3 (0.39) | NLRP3 | |
| SCHEMBL11625399 | 0.73 | NLRP3 (0.38) | NLRP3 | |
| SCHEMBL11623939 | 0.72 | KCNJ11 (0.73) | KCNJ11ABCC9ABCC8KCNJ8 | |
| SCHEMBL11623628 | 0.72 | SMN1; SMN2 (0.41) | NLRP3 | |
| SCHEMBL11624010 | 0.72 | NLRP3 (0.38) | NLRP3 | |
| SCHEMBL11625276 | 0.72 | NLRP3 (0.37) | NLRP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4093742-A | Anti-hypertensive polyhaloisopropyl-substituted arylureas | SCHERING CORPORATION (US) | 1978-06-06 | — | — | US | disclosed |