Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NLRP3 | Q96P20 | 15/20 | 0.45 |
| ▸ | NR1I3 | Q14994 | 1/20 | 0.33 |
| ▸ | CA2 | P00918 | 1/20 | 0.33 |
| ▸ | KCNJ11 | Q14654 | 1/20 | 0.33 |
| ▸ | CXCR2 | P25025 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11628629 | 0.90 | NLRP3 (0.47) | NLRP3KCNJ11 | |
| SCHEMBL11625399 | 0.85 | NLRP3 (0.38) | NLRP3CA2 | |
| SCHEMBL11624497 | 0.80 | L3MBTL1 (0.34) | NLRP3KCNJ11CXCR2 | |
| SCHEMBL11623944 | 0.75 | KCNJ11 (0.59) | KCNJ11 | |
| SCHEMBL11625276 | 0.74 | NLRP3 (0.37) | NLRP3CA2 | |
| SCHEMBL11625397 | 0.73 | NLRP3 (0.40) | NLRP3CA2KCNJ11 | |
| SCHEMBL11627766 | 0.73 | KCNJ11 (0.42) | KCNJ11 | |
| SCHEMBL11624010 | 0.71 | NLRP3 (0.38) | NLRP3 | |
| SCHEMBL11623631 | 0.71 | ALDH1A1 (0.38) | NLRP3 | |
| SCHEMBL11625273 | 0.71 | NLRP3 (0.39) | NLRP3CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4093742-A | Anti-hypertensive polyhaloisopropyl-substituted arylureas | SCHERING CORPORATION (US) | 1978-06-06 | — | — | US | disclosed |