Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.39 |
| ▸ | TAS2R8 | Q9NYW2 | 3/20 | 0.37 |
| ▸ | AR | P10275 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL314801 | 0.87 | MEN1 (0.45) | TDP1KMT2AMEN1GAAP2RX7 | |
| SCHEMBL12530346 | 0.80 | P2RX7 (0.42) | TDP1KMT2AMEN1GAAP2RX7 | |
| SCHEMBL11631555 | 0.78 | FFAR4 (0.41) | TDP1KMT2AMEN1GAAP2RX7 | |
| SCHEMBL12500526 | 0.76 | P2RX7 (0.44) | TDP1KMT2AMEN1GAAP2RX7 | |
| SCHEMBL7033953 | 0.75 | P2RX7 (0.46) | TDP1KMT2AMEN1GAAP2RX7 | |
| SCHEMBL314922 | 0.74 | TDP1 (0.49) | TDP1KMT2AMEN1GAAP2RX7 | |
| SCHEMBL4182412 | 0.72 | TDP1 (0.47) | TDP1KMT2AMEN1GAAP2RX7 | |
| SCHEMBL14302719 | 0.72 | P2RX7 (0.50) | TDP1KMT2AMEN1P2RX7ALDH1A1 | |
| SCHEMBL2172793 | 0.72 | P2RX7 (0.49) | KMT2AMEN1GAAP2RX7ALDH1A1 | |
| SCHEMBL3690521 | 0.72 | LMNA (0.41) | TDP1KMT2AMEN1GAAP2RX7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4080334-A | Intermediates in the total synthesis employing substituted isoxazole derivatives | HOFFMANN-LA ROCHE INC. (US) | 1978-03-21 | — | — | US | disclosed |
| US-4044004-A | Total steroid synthesis employing substituted isoxazole derivatives | HOFFMANN-LA ROCHE INC. (US) | 1977-08-23 | — | — | US | disclosed |
| US-3985771-A | Total steroid synthesis employing substituted isoxazole derivatives | HOFFMANN-LA ROCHE INC. (US) | 1976-10-12 | — | — | US | disclosed |
| US-3984427-A | Preparation of vinyl lactones and corresponding Mannich bases | HOFFMANN-LA ROCHE INC. (US) | 1976-10-05 | — | — | US | disclosed |
| US-3984428-A | Isoxazolyl-substituted perhydrobenzindenes | HOFFMANN-LA ROCHE INC. (US) | 1976-10-05 | — | — | US | disclosed |