Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Monoethanolamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | GAA | P10253 | 2/20 | 0.47 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 4/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | HTT | P42858 | 3/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | HCAR2 | Q8TDS4 | 2/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11628331 | 0.94 | ALDH1A1 (0.53) | ALDH1A1GAANOTUMTSHRLMNA | |
| SCHEMBL11628337 | 0.94 | ALDH1A1 (0.53) | ALDH1A1GAANOTUMTSHRLMNA | |
| Trolamine SCHEMBL11629192 | 0.90 | ALDH1A1 (0.46) | ALDH1A1GAANOTUMTSHRLMNA | |
| Potassium Ion SCHEMBL11624299 | 0.84 | ALDH1A1 (0.50) | ALDH1A1GAANOTUMTSHRLMNA | |
| Potassium Ion SCHEMBL11624303 | 0.84 | ALDH1A1 (0.50) | ALDH1A1GAANOTUMTSHRLMNA | |
| SCHEMBL11624556 | 0.82 | KMT2A (0.50) | ALDH1A1GAATSHRLMNAHTT | |
| Monoethanolamine SCHEMBL11628399 | 0.82 | NOTUM (0.51) | ALDH1A1GAANOTUMTSHRLMNA | |
| SCHEMBL11624400 | 0.79 | TSHR (0.45) | ALDH1A1GAATSHRLMNAHTT | |
| SCHEMBL11624201 | 0.78 | ALDH1A1 (0.46) | ALDH1A1GAATSHRLMNAHTT | |
| SCHEMBL11625604 | 0.76 | NOTUM (0.58) | ALDH1A1GAANOTUMTSHRLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4067988-A | 3-Phenyl-1,2,4-oxadiazole derivatives as antiinflammatory-antitussive agents | LABORATOIRES CASSENNE (FR) | 1978-01-10 | — | — | US | disclosed |