Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK8 | P45983 | 20/20 | 0.69 |
| ▸ | MAPK9 | P45984 | 10/20 | 0.69 |
| ▸ | MAPK10 | P53779 | 9/20 | 0.69 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6876597 | 0.85 | MAPK8 (0.84) | MAPK8MAPK9MAPK10 | |
| SCHEMBL1163081 | 0.82 | MAPK8 (0.77) | MAPK8MAPK9MAPK10 | |
| SCHEMBL1163009 | 0.82 | MAPK8 (1.00) | MAPK8MAPK9MAPK10 | |
| SCHEMBL1200959 | 0.82 | MAPK8 (1.00) | MAPK8MAPK9MAPK10 | |
| SCHEMBL6863903 | 0.80 | MAPK8 (0.68) | MAPK8MAPK9MAPK10 | |
| SCHEMBL1164180 | 0.79 | MAPK8 (0.66) | MAPK8MAPK9MAPK10 | |
| SCHEMBL6863683 | 0.76 | MAPK8 (1.00) | MAPK8MAPK9MAPK10 | |
| SCHEMBL1163195 | 0.76 | MAPK8 (1.00) | MAPK8MAPK9MAPK10 | |
| SCHEMBL27955714 | 0.74 | MAPK8 (0.67) | MAPK8MAPK9MAPK10 | |
| SCHEMBL5094147 | 0.74 | MAPK8 (0.56) | MAPK8MAPK9MAPK10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2464640-A1 | INHIBITORS OF JNK | F. Hoffmann-La Roche AG (CH) | 2012-06-20 | — | — | EP | disclosed |
| WO-2011018417-A1 | INHIBITORS OF JNK | F. HOFFMANN-LA ROCHE AG (CH) | 2011-02-17 | — | — | WO | disclosed |