Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK8 | P45983 | 13/20 | 0.56 |
| ▸ | MAPK9 | P45984 | 13/20 | 0.56 |
| ▸ | MAPK10 | P53779 | 11/20 | 0.56 |
| ▸ | MKNK1 | Q9BUB5 | 3/20 | 0.51 |
| ▸ | MKNK2 | Q9HBH9 | 3/20 | 0.51 |
| ▸ | CCNT1 | O60563 | 2/20 | 0.49 |
| ▸ | CDK1 | P06493 | 2/20 | 0.49 |
| ▸ | CCNB1 | P14635 | 2/20 | 0.49 |
| ▸ | CDK9 | P50750 | 2/20 | 0.49 |
| ▸ | CDK7 | P50613 | 1/20 | 0.49 |
| ▸ | CCNH | P51946 | 1/20 | 0.49 |
| ▸ | CCNE1 | P24864 | 4/20 | 0.39 |
| ▸ | CDK2 | P24941 | 4/20 | 0.39 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.36 |
| ▸ | LCK | P06239 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14768386 | 0.87 | MAPK8 (0.55) | MAPK8MAPK9MAPK10MKNK1MKNK2 | |
| SCHEMBL3809069 | 0.84 | MAPK8 (0.41) | MAPK8MAPK9MAPK10MKNK1MKNK2 | |
| SCHEMBL3810254 | 0.83 | MAPK8 (0.39) | MAPK8MAPK9MAPK10MKNK1MKNK2 | |
| SCHEMBL5094111 | 0.80 | MAPK8 (0.56) | MAPK8MAPK9MAPK10MKNK1MKNK2 | |
| SCHEMBL5096419 | 0.80 | CDK1 (0.51) | MAPK8MAPK9MAPK10MKNK1MKNK2 | |
| SCHEMBL3817313 | 0.79 | MAPK8 (0.47) | MAPK8MAPK9MAPK10MKNK1MKNK2 | |
| SCHEMBL3814433 | 0.77 | MAPK8 (0.50) | MAPK8MAPK9MAPK10MKNK1MKNK2 | |
| SCHEMBL4440166 | 0.76 | MAPK8 (0.39) | MAPK8MAPK9MAPK10MKNK1MKNK2 | |
| SCHEMBL14193418 | 0.76 | MAPK8 (0.79) | MAPK8MAPK9MAPK10MKNK1MKNK2 | |
| SCHEMBL8190587 | 0.76 | MAPK8 (0.73) | MAPK8MAPK9MAPK10MKNK1MKNK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8399462-B2 | 4-[4-(4-benzyloxy-indol-1-yl)-pyrimidin-2-ylamino]-cyclohexanol; autoimmune, inflammatory, metabolic, neurological diseases as well as cancer and pain | ROCHE PALO ALTO LLC (US) | 2013-03-19 | — | — | US | claimed |
| US-20080146565-A1 | JNK modulators | ROCHE PALO ALTO LLC | 2008-06-19 | — | — | US | claimed |
| US-8399462-B2 | 4-[4-(4-benzyloxy-indol-1-yl)-pyrimidin-2-ylamino]-cyclohexanol; autoimmune, inflammatory, metabolic, neurological diseases as well as cancer and pain | ROCHE PALO ALTO LLC (US) | 2013-03-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080146565-A1 | JNK modulators | MAPKAPK2, MAPKAPK3, MAP3K10 | MAPK8 40/4885MAPK9 43/4885MAPK10 31/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.