Known targets — ChEMBL curated mechanism
ADRB1ADRB2ATP4AATP4BAXLCHRM2CHRM3DRD2FLT3HRH1HTR2AHTR2BHTR2CKCNH2KMT2AMAP2K1MAP2K2MEN1MLNRPLK4RENS1PR1SLC6A2SLC6A4atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 known ✓ | P14416 | 10/20 | 0.46 |
| ▸ | MEN1 known ✓ | O00255 | 3/20 | 0.42 |
| ▸ | KMT2A known ✓ | Q03164 | 3/20 | 0.42 |
| ▸ | HTR2A known ✓ | P28223 | 3/20 | 0.40 |
| ▸ | CHRM2 known ✓ | P08172 | 3/20 | 0.40 |
| ▸ | CHRM3 known ✓ | P20309 | 3/20 | 0.40 |
| ▸ | KCNH2 known ✓ | Q12809 | 3/20 | 0.40 |
| ▸ | HTR2C known ✓ | P28335 | 2/20 | 0.40 |
| ▸ | HRH1 known ✓ | P35367 | 2/20 | 0.40 |
| ▸ | HTR2B known ✓ | P41595 | 2/20 | 0.40 |
| ▸ | ADRB2 known ✓ | P07550 | 1/20 | 0.39 |
| ▸ | SLC6A2 known ✓ | P23975 | 1/20 | 0.39 |
| ▸ | SLC6A4 known ✓ | P31645 | 1/20 | 0.39 |
| ▸ | HRH4 | Q9H3N8 | 3/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | DRD1 | P21728 | 6/20 | 0.40 |
| ▸ | ADRA2A | P08913 | 3/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL11633258 | 1.00 | HRH4 (0.51) | HRH4DRD2KDM4EMEN1KMT2A | |
| SCHEMBL11634221 | 0.90 | DRD2 (0.54) | HRH4DRD2KDM4EMEN1KMT2A | |
| Fumaric Acid SCHEMBL11632487 | 0.86 | HRH4 (0.54) | HRH4DRD2KDM4EMEN1KMT2A | |
| Fumaric Acid SCHEMBL11632484 | 0.86 | HRH4 (0.54) | HRH4DRD2KDM4EMEN1KMT2A | |
| SCHEMBL11636450 | 0.79 | DRD2 (0.59) | HRH4DRD2DRD1ADRA2AHTR2A | |
| SCHEMBL4431761 | 0.77 | DRD2 (0.57) | HRH4DRD2KDM4EMEN1KMT2A | |
| SCHEMBL11631895 | 0.77 | DRD2 (0.49) | HRH4DRD2KDM4EMEN1KMT2A | |
| Fumaric Acid SCHEMBL11479047 | 0.77 | DRD2 (0.55) | HRH4DRD2DRD1ADRA2AHTR2A | |
| Fumaric Acid SCHEMBL11479032 | 0.77 | DRD2 (0.55) | HRH4DRD2DRD1ADRA2AHTR2A | |
| SCHEMBL11633287 | 0.76 | DRD2 (0.57) | HRH4DRD2KDM4EMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4087421-A | NEUROLEPTIC, ANTI-DEPRESSANT AND ANALGESTIC ACTIVITY | AMERICAN CYANAMID COMPANY (US) | 1978-05-02 | — | — | US | claimed |
| US-4087421-A | NEUROLEPTIC, ANTI-DEPRESSANT AND ANALGESTIC ACTIVITY | AMERICAN CYANAMID COMPANY (US) | 1978-05-02 | — | — | US | disclosed |