SCHEMBL11633657

SCHEMBL11633657

COc1cc2c(cc1OC)Nc1cscc1C(N1CCN(C)CC1)=N2

nearest known ligand 0.51

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CHRM1 P11229 10/20 0.51
HRH1 P35367 3/20 0.47
PAK1 Q13153 1/20 0.47
DRD2 P14416 4/20 0.45
DRD4 P21917 4/20 0.45
DRD3 P35462 3/20 0.45
HTR3E A5X5Y0 2/20 0.45
MEN1 O00255 2/20 0.45
HTR3B O95264 2/20 0.45
ABCB11 O95342 2/20 0.45
LMNA P02545 2/20 0.45
ADRB2 P07550 2/20 0.45
CHRM2 P08172 2/20 0.45
CHRM4 P08173 2/20 0.45
HTR1A P08908 2/20 0.45
CHRM5 P08912 2/20 0.45
ADRA2A P08913 2/20 0.45
ADRA2B P18089 2/20 0.45
ADRA2C P18825 2/20 0.45
CHRM3 P20309 2/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11631009 0.84 CHRM1 (0.72) CHRM1HRH1PAK1DRD2DRD4
SCHEMBL11634162 0.84 CHRM1 (0.63) CHRM1HRH1PAK1DRD2DRD4
SCHEMBL11529616 0.83 CHRM1 (0.55) CHRM1HRH1PAK1DRD2DRD4
SCHEMBL11534075 0.83 CHRM1 (0.52) CHRM1HRH1PAK1DRD2DRD4
SCHEMBL11666986 0.80 CHRM1 (0.57) CHRM1HRH1PAK1DRD2DRD4
SCHEMBL11632479 0.80 CHRM1 (0.71) CHRM1HRH1PAK1DRD2DRD4
SCHEMBL11528161 0.80 DRD4 (0.52) CHRM1HRH1PAK1DRD2DRD4
SCHEMBL11631048 0.79 CHRM1 (0.61) CHRM1HRH1PAK1DRD2DRD4
SCHEMBL11633189 0.79 DRD2 (0.61) CHRM1HRH1DRD2DRD4DRD3
SCHEMBL11531362 0.79 CHRM1 (0.62) CHRM1HRH1PAK1DRD2DRD4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4087421-A NEUROLEPTIC, ANTI-DEPRESSANT AND ANALGESTIC ACTIVITY AMERICAN CYANAMID COMPANY (US) 1978-05-02 US disclosed
US-3951981-A NEUROLEPTIC, ANALGESIC AMERICAN CYANAMID COMPANY (US) 1976-04-20 US disclosed