Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 1/20 | 0.52 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.52 |
| ▸ | PNMT | P11086 | 1/20 | 0.49 |
| ▸ | TACR1 | P25103 | 4/20 | 0.47 |
| ▸ | ACP3 | P15309 | 2/20 | 0.46 |
| ▸ | IDO1 | P14902 | 1/20 | 0.43 |
| ▸ | TDO2 | P48775 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | CES2 | O00748 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | CETP | P11597 | 1/20 | 0.42 |
| ▸ | ATM | Q13315 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11632527 | 0.82 | HTR2A (0.59) | SLC6A2SLC6A4TACR1CYP3A4CYP2D6 | |
| SCHEMBL25304558 | 0.81 | PNMT (0.64) | SLC6A2SLC6A4PNMTTACR1ACP3 | |
| SCHEMBL11632884 | 0.78 | HTR2A (0.44) | SLC6A2SLC6A4TACR1IDO1TDO2 | |
| Clemeprol SCHEMBL499766 | 0.78 | SLC6A2 (0.50) | SLC6A2SLC6A4TACR1ACP3CYP3A4 | |
| Clemeprol SCHEMBL11132757 | 0.77 | SLC6A2 (0.49) | SLC6A2SLC6A4CYP3A4CYP2D6MEN1 | |
| SCHEMBL23021670 | 0.77 | PNMT (0.57) | PNMTTACR1ACP3IDO1TDO2 | |
| SCHEMBL25853632 | 0.76 | SLC6A4 (0.56) | SLC6A2SLC6A4PNMTTACR1ACP3 | |
| SCHEMBL11634860 | 0.76 | HTR2A (0.48) | SLC6A2SLC6A4CYP3A4CYP2D6MEN1 | |
| SCHEMBL683709 | 0.76 | IDO1 (0.53) | PNMTTACR1ACP3IDO1TDO2 | |
| SCHEMBL4135655 | 0.75 | PNMT (0.59) | PNMTACP3IDO1TDO2CES2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4113972-A | ANTIDEPRESSANTS | BEECHAM GROUP LIMITED (GB) | 1978-09-12 | — | — | US | disclosed |
| US-4101676-A | Diphenylpropylamines to treat depression | BEECHAM GROUP LIMITED (GB) | 1978-07-18 | — | — | US | disclosed |