Sugi Predict

Sugi Predict / Compounds / SCHEMBL4135655

SCHEMBL4135655

SCHEMBL4135655

OC(c1ccccc1)c1cccc(C(F)(F)F)c1

nearest known ligand 0.59

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ PNMT P11086 1/20 0.59
▸ ACP3 P15309 3/20 0.58
▸ IDO1 P14902 2/20 0.56
▸ TDO2 P48775 2/20 0.56
▸ CES2 O00748 1/20 0.54
▸ ALDH1A1 P00352 2/20 0.48
▸ TSHR P16473 1/20 0.48
▸ MAPT P10636 2/20 0.48
▸ HTT P42858 2/20 0.48
▸ LMNA P02545 1/20 0.48
▸ TP53 P04637 1/20 0.48
▸ XBP1 P17861 1/20 0.48
▸ SMN1; SMN2 Q16637 1/20 0.48
▸ S1PR3 Q99500 1/20 0.48
▸ GRIN2B Q13224 1/20 0.47
▸ OPRM1 P35372 1/20 0.47
▸ OPRD1 P41143 1/20 0.47
▸ OPRK1 P41145 1/20 0.47
▸ OPRL1 P41146 1/20 0.47
▸ L3MBTL1 Q9Y468 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4135956 0.94 PNMT (0.65) PNMTACP3IDO1TDO2CES2
SCHEMBL10889071 0.87 PNMT (0.54) PNMTACP3IDO1TDO2CES2
SCHEMBL23021670 0.87 PNMT (0.57) PNMTACP3IDO1TDO2CES2
SCHEMBL14033674 0.86 IDO1 (0.54) PNMTACP3IDO1TDO2MAPT
SCHEMBL31067471 0.85 TSHR (0.66) PNMTACP3IDO1TDO2CES2
SCHEMBL17073488 0.85 TSHR (0.66) PNMTACP3IDO1TDO2CES2
SCHEMBL11201464 0.82 KMT2A (0.54) PNMTACP3IDO1TDO2CES2
SCHEMBL11665754 0.82 PNMT (0.49) PNMTACP3IDO1TDO2CES2
SCHEMBL477694 0.82 ACP3 (0.59) ACP3CES2ALDH1A1TSHRSMN1; SMN2
SCHEMBL477425 0.82 ACP3 (0.59) ACP3CES2ALDH1A1TSHRSMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 35 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-119243184-A Electrochemical organic synthesis method of benzyl alcohol fluorinated product by using sulfur hexafluoride as fluorination reagent 国网安徽省电力有限公司电力科学研究院 2025-01-03 — — CN claimed
EP-2565183-A1 Glycine transporter-1 inhibitors Amgen Inc. (US) 2013-03-06 — — EP claimed
CN-119243184-A Electrochemical organic synthesis method of benzyl alcohol fluorinated product by using sulfur hexafluoride as fluorination reagent 国网安徽省电力有限公司电力科学研究院 2025-01-03 — — CN disclosed
CN-119191992-A Industrial preparation method of ortho-position large-steric-hindrance aniline 浙江巨化技术中心有限公司 2024-12-27 — — CN disclosed
US-9663476-B2 Glycine transporter-1 inhibitors AMGEN INC. (US) 2017-05-30 — — US disclosed
US-9365553-B2 Heterocyclic compound and H1 receptor antagonist ASKA PHARMACEUTICAL CO., LTD. (JP) 2016-06-14 — — US disclosed
US-9365553-B2 Heterocyclic compound and H1 receptor antagonist ASKA PHARMACEUTICAL CO., LTD. (JP) 2016-06-14 — — US disclosed
EP-2947067-A1 Glycine transporter-1 inhibitors Amgen, Inc (US) 2015-11-25 — — EP disclosed
US-20150307457-A1 GLYCINE TRANSPORTER-1 INHIBITORS AMGEN INC. (US) 2015-10-29 — — US disclosed
EP-2578569-B1 HETEROCYCLIC RING COMPOUND AND H1 RECEPTOR ANTAGONIST ASKA PHARM CO LTD (JP) 2015-10-28 — — EP disclosed
US-8735383-B2 Glycine transporter-1 inhibitors AMGEN INC. (US) 2014-05-27 — — US disclosed
US-20040259912-A1 Benzine derivatives, process for preparing the same and use thereof TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2004-12-23 — — US disclosed
EP-1437344-A1 BENZENE DERIVATIVES,PROCESS FOR PREPARING THE SAME AND USE THEREOF Takeda Chemical Industries, Ltd. (JP) 2004-07-14 — — EP disclosed
US-5321000-A Benzhydryl compounds as herbicide antidotes MONSANTO COMPANY (US) 1994-06-14 — — US disclosed
US-5162537-A To safen acetamide herbicids used to control grassy and broadleaf weeds in rice, sorghum and wheat MONSANTO COMPANY (US) 1992-11-10 — — US disclosed
US-4964893-A REDUCING INJURY TO A CROP PLANT MONSANTO COMPANY (US) 1990-10-23 — — US disclosed
US-4792635-A Symmetric benzophenones substituted by groups containing fluorine BAYER AKTIENGESELLSCHAFT (DE) 1988-12-20 — — US disclosed
EP-0156278-B1 PROCESS FOR THE PREPARATION OF SYMMETRICAL BENZOPHENONES SUBSTITUTED BY FLUOR-CONTAINING GROUPS, THEIR USE AND SYMMETRICAL BENZOPHENONES SUBSTITUTED BY FLUOR-CONTAINING GROUPS BAYER AG (DE) 1988-03-02 — — EP disclosed
EP-0156278-A2 Process for the preparation of symmetrical benzophenones substituted by fluor-containing groups, their use and symmetrical benzophenones substituted by fluor-containing groups BAYER AG (DE) 1985-10-02 — — EP disclosed
US-4082755-A NEUROLEPTIC JANSSEN PHARMACEUTICA N.V. (BE) 1978-04-04 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20150307457-A1 GLYCINE TRANSPORTER-1 INHIBITORS SLC18A2, SLC7A11, SLC6A5 PNMT 131/4885ACP3 4339/4885IDO1 287/4885
US-20040259912-A1 Benzine derivatives, process for preparing the same and use thereof HRH4, HRH2, HRH1 PNMT 555/4885ACP3 4636/4885IDO1 953/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.