Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 2/20 | 0.53 |
| ▸ | CHRM1 | P11229 | 7/20 | 0.43 |
| ▸ | HRH1 | P35367 | 3/20 | 0.42 |
| ▸ | PAK1 | Q13153 | 1/20 | 0.42 |
| ▸ | DRD2 | P14416 | 8/20 | 0.40 |
| ▸ | DRD4 | P21917 | 3/20 | 0.40 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.40 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.40 |
| ▸ | CHRM5 | P08912 | 2/20 | 0.40 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.40 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.40 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.40 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.40 |
| ▸ | DRD1 | P21728 | 2/20 | 0.40 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.40 |
| ▸ | HTR2A | P28223 | 2/20 | 0.40 |
| ▸ | HTR2C | P28335 | 2/20 | 0.40 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.40 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.40 |
| ▸ | HTR2B | P41595 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11532011 | 0.89 | CHRM1 (0.54) | HRH4CHRM1HRH1PAK1DRD2 | |
| SCHEMBL11631525 | 0.85 | HRH4 (0.74) | HRH4CHRM1HRH1DRD2DRD4 | |
| SCHEMBL11637152 | 0.83 | HRH4 (0.52) | HRH4CHRM1HRH1PAK1DRD2 | |
| SCHEMBL11635638 | 0.83 | HRH4 (0.62) | HRH4CHRM1HRH1DRD2DRD4 | |
| SCHEMBL11631603 | 0.80 | DRD2 (0.49) | HRH4CHRM1HRH1PAK1DRD2 | |
| SCHEMBL11533334 | 0.77 | HRH4 (0.54) | HRH4CHRM1HRH1DRD2DRD4 | |
| SCHEMBL11632479 | 0.76 | CHRM1 (0.71) | HRH4CHRM1HRH1PAK1DRD2 | |
| SCHEMBL11622903 | 0.76 | DRD4 (0.54) | HRH4CHRM1HRH1DRD2DRD4 | |
| SCHEMBL11666986 | 0.74 | CHRM1 (0.57) | HRH4CHRM1HRH1PAK1DRD2 | |
| SCHEMBL11533730 | 0.73 | CHRM1 (0.71) | HRH4CHRM1HRH1PAK1DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4087421-A | NEUROLEPTIC, ANTI-DEPRESSANT AND ANALGESTIC ACTIVITY | AMERICAN CYANAMID COMPANY (US) | 1978-05-02 | — | — | US | disclosed |
| US-3951981-A | NEUROLEPTIC, ANALGESIC | AMERICAN CYANAMID COMPANY (US) | 1976-04-20 | — | — | US | disclosed |