Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 7/20 | 0.48 |
| ▸ | HTR2A | P28223 | 5/20 | 0.44 |
| ▸ | HTR2C | P28335 | 4/20 | 0.44 |
| ▸ | HTR2B | P41595 | 4/20 | 0.44 |
| ▸ | HTR6 | P50406 | 4/20 | 0.40 |
| ▸ | HTR1D | P28221 | 3/20 | 0.38 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.38 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.38 |
| ▸ | HTR1B | P28222 | 2/20 | 0.37 |
| ▸ | HTR1E | P28566 | 2/20 | 0.37 |
| ▸ | HTR7 | P34969 | 2/20 | 0.37 |
| ▸ | HTR5A | P47898 | 2/20 | 0.37 |
| ▸ | MPO | P05164 | 1/20 | 0.37 |
| ▸ | DRD1 | P21728 | 1/20 | 0.37 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.37 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.37 |
| ▸ | DRD3 | P35462 | 1/20 | 0.37 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.36 |
| ▸ | HTR3B | O95264 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4395931 | 0.74 | HTR2A (0.57) | HTR1AHTR2AHTR2CHTR2BHTR6 | |
| SCHEMBL25532603 | 0.72 | HTR1A (0.50) | HTR1AHTR2AHTR2CHTR2BHTR6 | |
| SCHEMBL1163911 | 0.72 | HTR1A (0.48) | HTR1AHTR2AHTR2CHTR2BHTR6 | |
| SCHEMBL1163435 | 0.71 | MTNR1A (0.40) | HTR1AHTR2ACYP2D6MTNR1AMTNR1B | |
| SCHEMBL24420538 | 0.70 | HTR1A (0.69) | HTR1AHTR2AHTR2CHTR2BHTR6 | |
| SCHEMBL4401430 | 0.70 | HTR1A (0.78) | HTR1AHTR2AHTR2CHTR2BHTR6 | |
| SCHEMBL1163398 | 0.70 | HTR2A (0.66) | HTR1AHTR2AHTR2CHTR2BHTR6 | |
| SCHEMBL30483753 | 0.69 | HTR1A (0.67) | HTR1AHTR2AHTR2CHTR2BHTR6 | |
| SCHEMBL25282377 | 0.69 | HTR1A (0.67) | HTR1AHTR2AHTR2CHTR2BHTR6 | |
| SCHEMBL13592867 | 0.67 | HTR1A (0.50) | HTR1AHTR2AHTR2CHTR2BHTR6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2464227-A1 | COMPOUNDS AND METHODS OF USE THEREOF | Galenea Corporation (US) | 2012-06-20 | — | — | EP | disclosed |
| WO-2011019738-A1 | COMPOUNDS AND METHODS OF USE THEREOF | GALENEA CORPORATION (US) | 2011-02-17 | — | — | WO | disclosed |