Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | PDE3A | Q14432 | 9/20 | 0.38 |
| ▸ | PDE3B | Q13370 | 8/20 | 0.38 |
| ▸ | PDE4B | Q07343 | 4/20 | 0.38 |
| ▸ | PDE4A | P27815 | 2/20 | 0.38 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.38 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
| ▸ | PARP1 | P09874 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | NPY1R | P25929 | 1/20 | 0.36 |
| ▸ | NPY2R | P49146 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | AXL | P30530 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 2/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11637547 | 0.84 | SMN1; SMN2 (0.51) | SMN1; SMN2PDE3APDE3BPDE4BPDE4A | |
| SCHEMBL11657483 | 0.84 | SMN1; SMN2 (0.59) | SMN1; SMN2PDE3APDE3BPDE4BPDE4A | |
| SCHEMBL9686080 | 0.82 | SMN1; SMN2 (0.49) | SMN1; SMN2PDE3APDE3BPDE4BPDE4A | |
| SCHEMBL11634644 | 0.78 | PDE3A (0.47) | SMN1; SMN2PDE3APDE3BPDE4BPDE4A | |
| SCHEMBL11626246 | 0.78 | SMN1; SMN2 (0.59) | SMN1; SMN2PDE3APDE3BPDE4BPDE4A | |
| SCHEMBL11738995 | 0.77 | SMN1; SMN2 (0.46) | SMN1; SMN2PDE3APDE3BPDE4BPDE4A | |
| SCHEMBL11738136 | 0.76 | MEN1 (0.48) | SMN1; SMN2PDE3APDE3BPDE4BPDE4A | |
| SCHEMBL11702816 | 0.75 | SMN1; SMN2 (0.42) | SMN1; SMN2PDE3APDE3BPDE4BPDE4A | |
| SCHEMBL11702077 | 0.74 | SMN1; SMN2 (0.54) | SMN1; SMN2PDE3APDE3BPDE4BPDE4A | |
| SCHEMBL11743380 | 0.74 | SMN1; SMN2 (0.43) | SMN1; SMN2PDE3APDE3BPDE4BPDE4A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4082843-A | 3-(3-(3-Substituted amino-2-hydroxypropoxy)phenyl)-6-hydrazino pyridazines and their use as vasodilators and β-adrenergic blocking agents | SMITH KLINE & FRENCH LABORATORIES LIMITED (EN) | 1978-04-04 | — | — | US | disclosed |