Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 9/20 | 0.38 |
| ▸ | DRD1 | P21728 | 7/20 | 0.38 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.34 |
| ▸ | ROS1 | P08922 | 1/20 | 0.34 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.34 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.34 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.33 |
| ▸ | CSNK1G1 | Q9HCP0 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.32 |
| ▸ | GAA | P10253 | 2/20 | 0.32 |
| ▸ | NPC1 | O15118 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | RAB9A | P51151 | 2/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.32 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11637229 | 0.86 | NOX1 (0.35) | CHRM1 | |
| SCHEMBL11631360 | 0.85 | DRD2 (0.39) | DRD2DRD1CHRM1KCNH2SMN1; SMN2 | |
| SCHEMBL11633472 | 0.85 | CHRM1 (0.40) | CHRM1 | |
| SCHEMBL11630707 | 0.85 | CHRM1 (0.41) | DRD2DRD1CHRM1 | |
| SCHEMBL11631907 | 0.83 | CHRM1 (0.41) | DRD2DRD1CHRM1LRRK2KCNH2 | |
| SCHEMBL11632682 | 0.83 | RELA (0.34) | CHRM1NPC1RAB9AKDM4E | |
| SCHEMBL11637517 | 0.81 | DRD2 (0.37) | DRD2DRD1CHRM1KCNH2SMN1; SMN2 | |
| SCHEMBL11630740 | 0.77 | MAPT (0.36) | DRD2DRD1CHRM1KCNH2SMN1; SMN2 | |
| SCHEMBL11635587 | 0.75 | MAPT (0.42) | CHRM1SMN1; SMN2GAANPC1ALDH1A1 | |
| SCHEMBL11623011 | 0.72 | DRD4 (0.38) | DRD2SMN1; SMN2GAANPC1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4087421-A | NEUROLEPTIC, ANTI-DEPRESSANT AND ANALGESTIC ACTIVITY | AMERICAN CYANAMID COMPANY (US) | 1978-05-02 | — | — | US | disclosed |
| US-3951981-A | NEUROLEPTIC, ANALGESIC | AMERICAN CYANAMID COMPANY (US) | 1976-04-20 | — | — | US | disclosed |