SCHEMBL1163580

SCHEMBL1163580

Cc1ccc(N(C(=O)OC(C)(C)C)c2ccccc2)cc1Br

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 2/20 0.44
KMT2A Q03164 2/20 0.44
ATM Q13315 1/20 0.40
TDP1 Q9NUW8 1/20 0.40
L3MBTL1 Q9Y468 1/20 0.40
TSHR P16473 1/20 0.39
PTGIR P43119 2/20 0.39
GSK3B P49841 1/20 0.38
MT-CO2 P00403 1/20 0.38
CHRM4 P08173 3/20 0.37
CHRM3 P20309 3/20 0.37
NPSR1 Q6W5P4 2/20 0.37
LMNA P02545 1/20 0.37
HPGD P15428 2/20 0.36
ALDH1A1 P00352 1/20 0.36
CHRM5 P08912 2/20 0.35
CHRM1 P11229 2/20 0.35
NPC1 O15118 1/20 0.35
POLB P06746 1/20 0.35
RAB9A P51151 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1164018 0.83 L3MBTL1 (0.37) MEN1KMT2AATMTDP1L3MBTL1
SCHEMBL1163762 0.83 GSK3B (0.39) ATMTDP1L3MBTL1PTGIRGSK3B
SCHEMBL28440815 0.83 ATM (0.46) MEN1KMT2AATMTDP1L3MBTL1
SCHEMBL504005 0.82 L3MBTL1 (0.55) MEN1KMT2AATMTDP1L3MBTL1
SCHEMBL22272756 0.80 BRD4 (0.42) MEN1KMT2ATSHRMT-CO2NPSR1
SCHEMBL13148775 0.79 TDP1 (0.49) MEN1KMT2AATMTDP1L3MBTL1
SCHEMBL13148766 0.79 TDP1 (0.49) MEN1KMT2AATMTDP1L3MBTL1
SCHEMBL13148723 0.79 TDP1 (0.49) MEN1KMT2AATMTDP1L3MBTL1
SCHEMBL16627083 0.79 ATM (0.42) ATMTDP1L3MBTL1TSHRGSK3B
SCHEMBL5605319 0.79 ATM (0.45) MEN1KMT2AATMTDP1L3MBTL1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-111233908-A Benzoxaborol-1-ol compound and preparation method and application thereof 南京农业大学 2020-06-05 CN disclosed
WO-2011019612-A1 BORON-CONTAINING SMALL MOLECULES AS ANTIPROTOZOAL AGENTS ANACOR PHARMACEUTICALS, INC. (US) 2011-02-17 WO disclosed