Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.56 |
| ▸ | MAPT | P10636 | 4/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.51 |
| ▸ | POLB | P06746 | 2/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.47 |
| ▸ | MEN1 | O00255 | 5/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11755910 | 0.81 | LMNA (0.58) | LMNAMAPTALDH1A1KMT2AKDM4E | |
| SCHEMBL11727784 | 0.80 | LMNA (0.56) | LMNAMAPTALDH1A1KMT2AKDM4E | |
| SCHEMBL11635148 | 0.80 | LMNA (0.60) | LMNAALDH1A1KMT2ATDP1KDM4E | |
| SCHEMBL11641060 | 0.80 | LMNA (0.59) | LMNAMAPTALDH1A1KMT2AMEN1 | |
| SCHEMBL11760508 | 0.80 | LMNA (0.53) | LMNAMAPTALDH1A1KMT2AKDM4E | |
| SCHEMBL15752483 | 0.79 | LMNA (0.59) | LMNAMAPTALDH1A1KMT2AKDM4E | |
| Fexinidazole SCHEMBL1163575 | 0.78 | LMNA (0.57) | LMNAMAPTALDH1A1KMT2AMEN1 | |
| SCHEMBL11756723 | 0.78 | LMNA (0.54) | LMNAMAPTALDH1A1L3MBTL1KMT2A | |
| Fexinidazole Sulfone SCHEMBL11756026 | 0.78 | LMNA (0.54) | LMNAALDH1A1KMT2AKDM4ECYP2C19 | |
| Fexinidazole Sulfoxide SCHEMBL11730318 | 0.77 | LMNA (0.53) | LMNAMAPTALDH1A1KMT2AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4105763-A | 1-Methyl-2-(phenyl-oxymethyl)-5-nitro-imidazoles | HOECHST AKTIENGESELLSCHAFT (DE) | 1978-08-08 | — | — | US | disclosed |