SCHEMBL1163995

SCHEMBL1163995

CCC(Cl)(Cl)C(O)NC(=O)c1ccc(Br)cc1

nearest known ligand 0.53

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HPGD P15428 3/20 0.53
HTT P42858 2/20 0.49
CA12 O43570 1/20 0.47
MMP2 P08253 1/20 0.47
CA14 Q9ULX7 1/20 0.47
LMNA P02545 2/20 0.47
ALDH1A1 P00352 2/20 0.47
OGG1 O15527 1/20 0.46
TRPA1 O75762 1/20 0.46
HDAC3 O15379 4/20 0.45
HDAC1 Q13547 4/20 0.45
HDAC2 Q92769 4/20 0.45
HSP90AA1 P07900 1/20 0.45
KMT2A Q03164 1/20 0.45
POLB P06746 1/20 0.44
CTDSP1 Q9GZU7 1/20 0.44
SMN1; SMN2 Q16637 1/20 0.43
HDAC10 Q969S8 1/20 0.43
HDAC11 Q96DB2 1/20 0.43
HDAC8 Q9BY41 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1242290 0.82 HPGD (0.70) HPGDHTTCA12MMP2CA14
SCHEMBL1164220 0.76 TRPA1 (0.50) HTTCA12MMP2CA14LMNA
SCHEMBL1923460 0.76 CA12 (0.54) HPGDHTTCA12MMP2CA14
SCHEMBL1164028 0.72 TRPA1 (0.55) HPGDHTTCA12MMP2CA14
SCHEMBL11604284 0.72 KDM4E (0.54) HPGDHTTLMNAALDH1A1TRPA1
SCHEMBL13062204 0.71 ALDH1A1 (0.64) HPGDHTTCA12MMP2CA14
SCHEMBL21241696 0.70 CA12 (0.56) HPGDHTTCA12MMP2CA14
SCHEMBL26263205 0.70 ALDH1A1 (0.54) CA12MMP2CA14LMNAALDH1A1
SCHEMBL966937 0.70 HTT (0.58) HPGDHTTCA12MMP2CA14
SCHEMBL12706071 0.70 ALDH1A1 (0.71) HPGDHTTCA12MMP2CA14

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20120190694-A1 SELECTIVE SPHINGOSINE-1-PHOSPHATE RECEPTOR ANTAGONISTS ALLERGAN, INC. (US) 2012-07-26 US disclosed
US-20120190694-A1 SELECTIVE SPHINGOSINE-1-PHOSPHATE RECEPTOR ANTAGONISTS ALLERGAN, INC. (US) 2012-07-26 US disclosed
US-20120190694-A1 SELECTIVE SPHINGOSINE-1-PHOSPHATE RECEPTOR ANTAGONISTS ALLERGAN, INC. (US) 2012-07-26 US disclosed
EP-2464629-A1 SELECTIVE SPHINGOSINE-1-PHOSPHATE RECEPTOR ANTAGONISTS Allergan, Inc. (US) 2012-06-20 EP disclosed
US-8168795-B2 Selective sphingosine-1-phosphate receptor antagonists ALLERGAN, INC. (US) 2012-05-01 US disclosed
US-8168795-B2 Selective sphingosine-1-phosphate receptor antagonists ALLERGAN, INC. (US) 2012-05-01 US disclosed
US-8168795-B2 Selective sphingosine-1-phosphate receptor antagonists ALLERGAN, INC. (US) 2012-05-01 US disclosed
WO-2011028927-A1 SELECTIVE SPHINGOSINE-1-PHOSPHATE RECEPTOR ANTAGONISTS ALLERGAN, INC. (US) 2011-03-10 WO disclosed
WO-2011019681-A1 SELECTIVE SPHINGOSINE-1-PHOSPHATE RECEPTOR ANTAGONISTS ALLERGAN, INC. (US) 2011-02-17 WO disclosed
US-20110039866-A1 SELECTIVE SPHINGOSINE-1-PHOSPHATE RECEPTOR ANTAGONISTS ALLERGAN, INC. (US) 2011-02-17 US disclosed
US-20110039866-A1 SELECTIVE SPHINGOSINE-1-PHOSPHATE RECEPTOR ANTAGONISTS ALLERGAN, INC. (US) 2011-02-17 US disclosed
US-20110039866-A1 SELECTIVE SPHINGOSINE-1-PHOSPHATE RECEPTOR ANTAGONISTS ALLERGAN, INC. (US) 2011-02-17 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120190694-A1 SELECTIVE SPHINGOSINE-1-PHOSPHATE RECEPTOR ANTAGONISTS S1PR3, S1PR1, S1PR2 HPGD 3667/4885HTT 3427/4885CA12 4826/4885
US-20110039866-A1 SELECTIVE SPHINGOSINE-1-PHOSPHATE RECEPTOR ANTAGONISTS S1PR3, S1PR1, S1PR2 HPGD 3667/4885HTT 3427/4885CA12 4826/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.