Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Adipic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 4/20 | 0.42 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.42 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.42 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.42 |
| ▸ | KDM5A | P29375 | 2/20 | 0.41 |
| ▸ | PHF8 | Q9UPP1 | 2/20 | 0.41 |
| ▸ | KDM2A | Q9Y2K7 | 2/20 | 0.41 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.41 |
| ▸ | KDM4A | O75164 | 1/20 | 0.41 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.41 |
| ▸ | BBOX1 | O75936 | 1/20 | 0.41 |
| ▸ | PPARG | P37231 | 4/20 | 0.40 |
| ▸ | PPARD | Q03181 | 4/20 | 0.40 |
| ▸ | PPARA | Q07869 | 4/20 | 0.40 |
| ▸ | GPR84 | Q9NQS5 | 3/20 | 0.40 |
| ▸ | HDAC11 | Q96DB2 | 3/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hexanoate SCHEMBL3416257 | 0.93 | AKR1B1 (0.55) | ALDH1A1TSHRAKR1B1PPARGPPARD | |
| Heptanoate SCHEMBL3415815 | 0.91 | GPR84 (0.57) | ALDH1A1TSHRAKR1B1PPARGPPARD | |
| Octanoic Acid SCHEMBL3416796 | 0.91 | GPR84 (0.57) | ALDH1A1TSHRAKR1B1PPARGPPARD | |
| Heptanoate SCHEMBL3414292 | 0.91 | GPR84 (0.57) | ALDH1A1TSHRAKR1B1PPARGPPARD | |
| Valeric Acid SCHEMBL3408060 | 0.91 | AKR1B1 (0.47) | ALDH1A1TSHRAKR1B1PPARGPPARD | |
| Butyric Acid SCHEMBL3410871 | 0.86 | FFAR3 (0.50) | ALDH1A1LMNAAKR1B1 | |
| Propionic Acid SCHEMBL3409829 | 0.85 | ALDH1A1 (0.50) | ALDH1A1 | |
| SCHEMBL2676656 | 0.85 | ALDH1A1 (0.44) | ALDH1A1LMNAEPHX1TSHRNFKB1 | |
| Malonic Acid SCHEMBL3708673 | 0.83 | ALDH1A1 (0.49) | ALDH1A1LMNAKMT2A | |
| SCHEMBL21891513 | 0.82 | ALDH1A1 (0.57) | ALDH1A1LMNAEPHX1TSHRNFKB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4120928-A | MELT EXTRUSION, STRETCHING | TOYO BOSEKI KABUSHIKI KAISHA (JP) | 1978-10-17 | — | — | US | disclosed |