SCHEMBL11643109

SCHEMBL11643109

Cc1ccc(-c2cc3ccc4ccccc4c3o2)cc1

nearest known ligand 0.62

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAOB P27338 3/20 0.54
MAOA P21397 2/20 0.54
CYP1A1 P04798 11/20 0.53
CYP1B1 Q16678 11/20 0.53
CYP1A2 P05177 10/20 0.53
PRKDC P78527 2/20 0.53
ABCB1 P08183 2/20 0.53
ABCC1 P33527 2/20 0.53
ABCG2 Q9UNQ0 2/20 0.53
KDM4E B2RXH2 1/20 0.53
PDE5A O76074 1/20 0.53
ALDH1A1 P00352 1/20 0.53
TP53 P04637 1/20 0.53
CYP3A4 P08684 1/20 0.53
CYP2D6 P10635 1/20 0.53
MAPT P10636 1/20 0.53
CYP19A1 P11511 1/20 0.53
CYP2C9 P11712 1/20 0.53
HPGD P15428 1/20 0.53
TSHR P16473 1/20 0.53

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11646604 0.86 CYP1A1 (0.68) MAOBMAOACYP1A1CYP1B1CYP1A2
SCHEMBL12279194 0.84 CSNK2A2 (0.49) MAOBMAOACSNK2A2CSNK2BCSNK2A1
SCHEMBL11643021 0.83 MAOB (0.62) MAOBMAOACYP1A1CYP1B1CYP1A2
SCHEMBL11645034 0.83 CYP1A1 (0.71) CYP1A1CYP1B1CYP1A2PRKDCABCB1
SCHEMBL11645931 0.83 CYP1A1 (0.71) CYP1A1CYP1B1CYP1A2PRKDCABCB1
SCHEMBL11645031 0.83 CYP1A1 (0.53) MAOBMAOACYP1A1CYP1B1CYP1A2
SCHEMBL20594586 0.83 CYP1A1 (0.78) CYP1A1CYP1B1CYP1A2PRKDCABCB1
SCHEMBL29407618 0.83 CYP1A1 (0.78) CYP1A1CYP1B1CYP1A2PRKDCABCB1
SCHEMBL1742227 0.83 CYP1A1 (0.73) MAOBCYP1A1CYP1B1CYP1A2ABCB1
SCHEMBL24368338 0.82 CYP1A1 (0.51) MAOBMAOACYP1A1CYP1B1CYP1A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4111962-A Certain substituted 2-phenylnaphtho[1,2-b]furane and -[2,1-b]furane STERLING DRUG INC. (US) 1978-09-05 US disclosed
US-3993645-A Stilbene optical brighteners and compositions brightened therewith STERLING DRUG INC. (US) 1976-11-23 US disclosed
US-3974144-A BENZOFURAN, BENZOTHIOPHENE, NAPHTHOFURAN, OPTICAL BRIGHTENER STERLING DRUG INC. (US) 1976-08-10 US disclosed
US-3932301-A NYLON, POLYESTERS STERLING DRUG INC. (US) 1976-01-13 US disclosed