Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 10/20 | 0.61 |
| ▸ | BCHE | P06276 | 1/20 | 0.55 |
| ▸ | ACHE | P22303 | 1/20 | 0.55 |
| ▸ | RAB9A | P51151 | 11/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 7/20 | 0.54 |
| ▸ | HPGD | P15428 | 2/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.54 |
| ▸ | TP53 | P04637 | 1/20 | 0.54 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.54 |
| ▸ | HAVCR2 | Q8TDQ0 | 1/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 5/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.53 |
| ▸ | GRM5 | P41594 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 3/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.52 |
| ▸ | ELANE | P08246 | 1/20 | 0.52 |
| ▸ | GAA | P10253 | 1/20 | 0.52 |
| ▸ | PKM | P14618 | 1/20 | 0.52 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12910362 | 0.81 | NPC1 (0.77) | NPC1RAB9ASMN1; SMN2HPGDL3MBTL1 | |
| SCHEMBL220919 | 0.81 | RAB9A (0.50) | NPC1RAB9ASMN1; SMN2HPGDL3MBTL1 | |
| SCHEMBL219490 | 0.81 | RAB9A (0.50) | NPC1RAB9ASMN1; SMN2HPGDL3MBTL1 | |
| SCHEMBL220108 | 0.81 | RAB9A (0.59) | NPC1RAB9ASMN1; SMN2L3MBTL1MAPT | |
| SCHEMBL12910371 | 0.80 | NPC1 (0.75) | NPC1RAB9ASMN1; SMN2HPGDL3MBTL1 | |
| SCHEMBL2491306 | 0.80 | MMP2 (0.72) | NPC1RAB9ASMN1; SMN2L3MBTL1MAPT | |
| SCHEMBL220196 | 0.79 | MEN1 (0.62) | NPC1BCHEACHERAB9ASMN1; SMN2 | |
| SCHEMBL12910358 | 0.79 | NPC1 (0.73) | NPC1RAB9ASMN1; SMN2HPGDL3MBTL1 | |
| SCHEMBL7258572 | 0.79 | SMN1; SMN2 (0.64) | NPC1RAB9ASMN1; SMN2HPGDTP53 | |
| SCHEMBL4695650 | 0.79 | RAB9A (0.50) | NPC1BCHEACHERAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4131677-A | Anti-inflammatory oxazolo [5,4-b]pyridines | MERCK & CO., INC. (US) | 1978-12-26 | — | — | US | disclosed |
| US-4038396-A | ANTIPYRETICS, ANALGESICS | MERCK & CO., INC. (US) | 1977-07-26 | — | — | US | disclosed |