Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 15/20 | 0.52 |
| ▸ | RAB9A | P51151 | 12/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 12/20 | 0.52 |
| ▸ | MEN1 | O00255 | 11/20 | 0.52 |
| ▸ | NPC1 | O15118 | 10/20 | 0.52 |
| ▸ | GAA | P10253 | 9/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 9/20 | 0.48 |
| ▸ | TP53 | P04637 | 2/20 | 0.48 |
| ▸ | LMNA | P02545 | 7/20 | 0.46 |
| ▸ | POLB | P06746 | 3/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.46 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.46 |
| ▸ | MBD2 | Q9UBB5 | 1/20 | 0.45 |
| ▸ | NFKB1 | P19838 | 5/20 | 0.44 |
| ▸ | NFKB2 | Q00653 | 5/20 | 0.44 |
| ▸ | RELA | Q04206 | 5/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.44 |
| ▸ | BLM | P54132 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1164672 | 1.00 | MAPT (0.52) | MAPTRAB9AKMT2AMEN1NPC1 | |
| SCHEMBL1165591 | 0.83 | MAPT (0.68) | MAPTRAB9AKMT2AMEN1NPC1 | |
| SCHEMBL1165592 | 0.83 | MAPT (0.68) | MAPTRAB9AKMT2AMEN1NPC1 | |
| SCHEMBL12506258 | 0.82 | MAPT (0.54) | MAPTRAB9AKMT2AMEN1NPC1 | |
| SCHEMBL12506257 | 0.82 | MAPT (0.54) | MAPTRAB9AKMT2AMEN1NPC1 | |
| SCHEMBL21010612 | 0.76 | MAPT (0.68) | MAPTRAB9AKMT2AMEN1NPC1 | |
| SCHEMBL1231354 | 0.73 | MAPT (0.70) | MAPTRAB9AKMT2AMEN1NPC1 | |
| SCHEMBL1231353 | 0.73 | MAPT (0.70) | MAPTRAB9AKMT2AMEN1NPC1 | |
| SCHEMBL1132583 | 0.73 | MAPT (0.58) | MAPTRAB9AKMT2AMEN1NPC1 | |
| SCHEMBL1132582 | 0.73 | MAPT (0.58) | MAPTRAB9AKMT2AMEN1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2488485-A1 | ENHANCERS OF PROTEIN DEGRADATION | Max-Delbrück-Centrum für Molekulare Medizin (DE) | 2012-08-22 | — | — | EP | disclosed |
| WO-2011020883-A9 | ENHANCERS OF PROTEIN DEGRADATION | Max-Delbrück-Centrum für Molekulare Medizin (DE) | 2012-07-12 | — | — | WO | disclosed |
| WO-2011020883-A1 | ENHANCERS OF PROTEIN DEGRADATION | Max-Delbrück-Centrum für Molekulare Medizin (DE) | 2011-02-24 | — | — | WO | disclosed |