Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB2 | P07550 | 6/20 | 0.70 |
| ▸ | ADRB1 | P08588 | 4/20 | 0.70 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.70 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.70 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.70 |
| ▸ | CYP2J2 | P51589 | 1/20 | 0.70 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.70 |
| ▸ | LMNA | P02545 | 2/20 | 0.64 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.64 |
| ▸ | CNR1 | P21554 | 1/20 | 0.64 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.64 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.64 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.64 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.64 |
| ▸ | GLA | P06280 | 1/20 | 0.64 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.64 |
| ▸ | TSHR | P16473 | 1/20 | 0.64 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.64 |
| ▸ | THPO | P40225 | 1/20 | 0.64 |
| ▸ | BLM | P54132 | 1/20 | 0.64 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11651404 | 0.92 | ADRB2 (0.73) | ADRB2ADRB1ADRA1ACYP2D6NR3C1 | |
| SCHEMBL15159029 | 0.89 | ADRB2 (0.73) | ADRB2ADRB1ADRA1ACYP2D6NR3C1 | |
| SCHEMBL31070234 | 0.88 | ADRB2 (0.71) | ADRB2ADRB1ADRA1ACYP2D6NR3C1 | |
| SCHEMBL13148928 | 0.88 | ADRB2 (0.71) | ADRB2ADRB1ADRA1ACYP2D6NR3C1 | |
| SCHEMBL5631180 | 0.87 | PTGS1 (0.68) | ADRB2ADRB1ADRA1ACYP2D6NR3C1 | |
| SCHEMBL8348602 | 0.87 | PTGS1 (0.68) | ADRB2ADRB1ADRA1ACYP2D6NR3C1 | |
| SCHEMBL11855880 | 0.85 | ADRB2 (0.85) | ADRB2ADRB1ADRA1ACYP2D6NR3C1 | |
| SCHEMBL13204479 | 0.85 | ADRB2 (0.75) | ADRB2ADRB1ADRA1ACYP2D6NR3C1 | |
| SCHEMBL3462992 | 0.85 | ADRB2 (0.75) | ADRB2ADRB1ADRA1ACYP2D6NR3C1 | |
| SCHEMBL9452302 | 0.83 | ADRB2 (0.73) | ADRB2ADRB1ADRA1ACYP2D6NR3C1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4078146-A | TREATMENT OF CARDIO-VASCULAR DISORDERS | AKTIEBOLAGET HASSLE (SW) | 1978-03-07 | — | — | US | disclosed |
| US-4035420-A | CARDIOVASCULAR DISORDERS | AKTIEBOLAGET HASSLE (SW) | 1977-07-12 | — | — | US | disclosed |
| US-3998790-A | PHENOXY-HYDROXYPROPYLAMINES, THEIR PREPARATION, AND METHOD AND PHARMACEUTICAL PREPARATIONS FOR TREATING CARDIOVASCULAR DISEASES | AKTIEBOLAGET HASSLE (SW) | 1976-12-21 | — | — | US | disclosed |