Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCL1 | Q07820 | 3/20 | 0.55 |
| ▸ | HPGD | P15428 | 1/20 | 0.55 |
| ▸ | TSHR | P16473 | 1/20 | 0.55 |
| ▸ | ACLY | P53396 | 10/20 | 0.45 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.44 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.44 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | CA1 | P00915 | 2/20 | 0.42 |
| ▸ | CA2 | P00918 | 2/20 | 0.42 |
| ▸ | PTGES2 | Q9H7Z7 | 1/20 | 0.40 |
| ▸ | EP300 | Q09472 | 1/20 | 0.39 |
| ▸ | APP | P05067 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11651478 | 0.88 | MCL1 (0.56) | MCL1HPGDTSHRACLYERBB2 | |
| SCHEMBL11653139 | 0.84 | MCL1 (0.47) | MCL1HPGDTSHRACLYHSP90AA1 | |
| SCHEMBL11651537 | 0.84 | ACLY (0.41) | MCL1HPGDTSHRACLYERBB2 | |
| SCHEMBL11655008 | 0.80 | HSD17B10 (0.42) | MCL1HPGDTSHRACLYHSP90AA1 | |
| SCHEMBL11656624 | 0.77 | ACLY (0.62) | HPGDTSHRACLYGAACA1 | |
| SCHEMBL11655514 | 0.76 | ACLY (0.49) | MCL1HPGDTSHRACLYERBB2 | |
| SCHEMBL11654620 | 0.75 | CDK1 (0.47) | HPGDACLYHSP90AA1HSP90AB1GAA | |
| SCHEMBL11656512 | 0.73 | ACLY (0.42) | ACLY | |
| SCHEMBL11027219 | 0.70 | ERBB2 (0.71) | MCL1HPGDTSHRERBB2HSP90AA1 | |
| SCHEMBL30197915 | 0.69 | HSD17B10 (0.52) | MCL1HPGDTSHRACLYERBB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4123553-A | ANTHELMINTICS | HOFFMANN-LA ROCHE INC. (US) | 1978-10-31 | — | — | US | claimed |
| US-4034110-A | Anthelmintics effective against liver flukes | HOFFMANN-LA ROCHE INC. (US) | 1977-07-05 | — | — | US | claimed |
| US-4123553-A | ANTHELMINTICS | HOFFMANN-LA ROCHE INC. (US) | 1978-10-31 | — | — | US | disclosed |
| US-4034110-A | Anthelmintics effective against liver flukes | HOFFMANN-LA ROCHE INC. (US) | 1977-07-05 | — | — | US | disclosed |