Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCL1 | Q07820 | 3/20 | 0.47 |
| ▸ | EP300 | Q09472 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 3/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | BRAF | P15056 | 1/20 | 0.42 |
| ▸ | ACLY | P53396 | 5/20 | 0.41 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.40 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.40 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | CCR2 | P41597 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11655008 | 0.89 | HSD17B10 (0.42) | MCL1EP300HPGDHSD17B10MEN1 | |
| SCHEMBL11655980 | 0.84 | MCL1 (0.55) | MCL1EP300HPGDGAAACLY | |
| SCHEMBL11651478 | 0.84 | MCL1 (0.56) | MCL1EP300HPGDMEN1KMT2A | |
| SCHEMBL11651537 | 0.83 | ACLY (0.41) | MCL1EP300HPGDHSD17B10MEN1 | |
| SCHEMBL11655514 | 0.81 | ACLY (0.49) | MCL1HPGDHSD17B10MEN1KMT2A | |
| SCHEMBL11744137 | 0.81 | PLA2G1B (0.39) | MCL1EP300HPGDHSD17B10MEN1 | |
| SCHEMBL11654620 | 0.80 | CDK1 (0.47) | HPGDHSD17B10ALDH1A1GAAALOX15 | |
| SCHEMBL11656624 | 0.79 | ACLY (0.62) | HPGDHSD17B10ALDH1A1GAAALOX15 | |
| SCHEMBL11650550 | 0.75 | ACLY (0.67) | MCL1ACLYCCR2 | |
| SCHEMBL11652092 | 0.75 | PLA2G1B (0.42) | MCL1HSD17B10MEN1KMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4123553-A | ANTHELMINTICS | HOFFMANN-LA ROCHE INC. (US) | 1978-10-31 | — | — | US | claimed |
| US-4034110-A | Anthelmintics effective against liver flukes | HOFFMANN-LA ROCHE INC. (US) | 1977-07-05 | — | — | US | claimed |
| US-4123553-A | ANTHELMINTICS | HOFFMANN-LA ROCHE INC. (US) | 1978-10-31 | — | — | US | disclosed |
| US-4034110-A | Anthelmintics effective against liver flukes | HOFFMANN-LA ROCHE INC. (US) | 1977-07-05 | — | — | US | disclosed |