SCHEMBL11656262

SCHEMBL11656262

O=C(O)c1ccc(C(=O)O)c2cnccc12

nearest known ligand 0.53

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDM4C Q9H3R0 12/20 0.53
KDM6B O15054 6/20 0.53
KDM4E B2RXH2 4/20 0.53
KDM4D Q6B0I6 4/20 0.53
KDM4A O75164 3/20 0.53
ALDH1A1 P00352 2/20 0.53
L3MBTL1 Q9Y468 2/20 0.53
MEN1 O00255 1/20 0.53
MAPT P10636 1/20 0.53
THRB P10828 1/20 0.53
KMT2A Q03164 1/20 0.53
TDP1 Q9NUW8 1/20 0.53
NAPRT Q6XQN6 1/20 0.43
CYP1A2 P05177 1/20 0.42
CSNK2A2 P19784 2/20 0.42
CSNK2B P67870 2/20 0.42
HTT P42858 1/20 0.42
APP P05067 1/20 0.42
GAA P10253 1/20 0.42
HCAR3 P49019 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14589054 0.87 KDM4E (0.59) KDM4CKDM6BKDM4EKDM4DKDM4A
SCHEMBL28496431 0.82 ASPH (0.45) KDM4CKDM6BKDM4EKDM4DKDM4A
SCHEMBL18113459 0.81 MAPT (0.52) KDM4CKDM6BKDM4EKDM4DKDM4A
SCHEMBL5800319 0.78 MAPT (0.56) KDM4EALDH1A1L3MBTL1MAPTTDP1
SCHEMBL8415023 0.76 KDM4C (0.52) KDM4CKDM6BKDM4EKDM4DKDM4A
SCHEMBL8413518 0.76 KDM4C (0.52) KDM4CKDM6BKDM4EKDM4DKDM4A
SCHEMBL2223329 0.76 NR4A1 (0.60) KDM4CKDM6BKDM4EKDM4DKDM4A
SCHEMBL117921 0.76 NR4A1 (0.60) KDM4CKDM6BKDM4EKDM4DKDM4A
SCHEMBL31522172 0.76 NR4A1 (0.60) KDM4CKDM6BKDM4EKDM4DKDM4A
SCHEMBL29702097 0.76 NR4A1 (0.60) KDM4CKDM6BKDM4EKDM4DKDM4A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4093622-A Pyridine esters of cyclopropane-carboxylic acid ZOECON CORPORATION (US) 1978-06-06 US disclosed