Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.59 |
| ▸ | KDM4C | Q9H3R0 | 4/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.59 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.59 |
| ▸ | MEN1 | O00255 | 2/20 | 0.59 |
| ▸ | MAPT | P10636 | 2/20 | 0.59 |
| ▸ | THRB | P10828 | 2/20 | 0.59 |
| ▸ | KDM6B | O15054 | 1/20 | 0.59 |
| ▸ | KDM4A | O75164 | 1/20 | 0.59 |
| ▸ | KDM4D | Q6B0I6 | 1/20 | 0.59 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.59 |
| ▸ | EP300 | Q09472 | 1/20 | 0.53 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.53 |
| ▸ | KAT8 | Q9H7Z6 | 1/20 | 0.53 |
| ▸ | AXL | P30530 | 1/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11656262 | 0.87 | KDM4C (0.53) | KDM4EKDM4CKMT2AALDH1A1TDP1 | |
| SCHEMBL14589053 | 0.80 | ALDH1A1 (0.64) | KDM4EKDM4CKMT2AALDH1A1TDP1 | |
| SCHEMBL5894746 | 0.78 | AXL (0.72) | KDM4EKDM4CKMT2AALDH1A1TDP1 | |
| SCHEMBL30785801 | 0.75 | KDM4C (0.70) | KDM4EKDM4CKMT2AALDH1A1TDP1 | |
| SCHEMBL29270366 | 0.75 | KDM4C (1.00) | KDM4EKDM4CKMT2AALDH1A1TDP1 | |
| SCHEMBL29643531 | 0.75 | KDM4C (1.00) | KDM4EKDM4CKMT2AALDH1A1TDP1 | |
| SCHEMBL220890 | 0.75 | KDM4C (0.70) | KDM4EKDM4CKMT2AALDH1A1TDP1 | |
| SCHEMBL535569 | 0.75 | KDM4C (1.00) | KDM4EKDM4CKMT2AALDH1A1TDP1 | |
| SCHEMBL244632 | 0.75 | KDM4C (0.70) | KDM4EKDM4CKMT2AALDH1A1TDP1 | |
| SCHEMBL629199 | 0.75 | CDC25B (0.54) | KDM4EKMT2AALDH1A1TDP1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7183411-B2 | Naphthol, quinoline and isoquinoline-derived urea modulators of vanilloid VR1 receptor | JANSSEN PHARMACEUTICA N.V. (BE) | 2007-02-27 | — | — | US | disclosed |
| US-7183411-B2 | Naphthol, quinoline and isoquinoline-derived urea modulators of vanilloid VR1 receptor | JANSSEN PHARMACEUTICA N.V. (BE) | 2007-02-27 | — | — | US | disclosed |