Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B2 | P19099 | 1/20 | 0.41 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.36 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.36 |
| ▸ | HCAR1 | Q9BXC0 | 1/20 | 0.36 |
| ▸ | DRD2 | P14416 | 1/20 | 0.34 |
| ▸ | DRD4 | P21917 | 1/20 | 0.34 |
| ▸ | GABRP | O00591 | 1/20 | 0.34 |
| ▸ | GABRD | O14764 | 1/20 | 0.34 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.34 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.34 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.34 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.34 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.34 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.34 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.34 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.34 |
| ▸ | GABRA4 | P48169 | 1/20 | 0.34 |
| ▸ | GABRE | P78334 | 1/20 | 0.34 |
| ▸ | GABRA6 | Q16445 | 1/20 | 0.34 |
| ▸ | GABRG1 | Q8N1C3 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1165308 | 0.91 | DYRK1A (0.36) | CYP11B2MKNK2DYRK1AHCAR1GABRP | |
| SCHEMBL1165201 | 0.80 | MGAM (0.45) | CYP11B2MKNK2DYRK1A | |
| SCHEMBL1165202 | 0.80 | MGAM (0.45) | CYP11B2MKNK2DYRK1A | |
| SCHEMBL27703232 | 0.73 | DRD2 (0.39) | CYP11B2DRD2DRD4MAP3K11CRBN | |
| SCHEMBL31144604 | 0.73 | DYRK1A (0.38) | CYP11B2MKNK2DYRK1AHCAR1GABRP | |
| SCHEMBL1165240 | 0.72 | ATM (0.49) | CYP11B2ATM | |
| SCHEMBL1166009 | 0.72 | CYP11B2 (0.53) | CYP11B2ALDH1A1 | |
| SCHEMBL1165258 | 0.72 | PDE10A (0.47) | HCAR1ALDH1A1 | |
| SCHEMBL14852087 | 0.71 | JAK3 (0.44) | ESR2ALDH1A1 | |
| SCHEMBL1165635 | 0.71 | ATM (0.42) | CYP11B2DYRK1ADRD2ATMHRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8058289-B2 | Pyridine methylene azolidinones and use thereof phosphoinositide inhibitors | MERCK SERONO SA (CH) | 2011-11-15 | — | — | US | disclosed |
| US-8058289-B2 | Pyridine methylene azolidinones and use thereof phosphoinositide inhibitors | MERCK SERONO SA (CH) | 2011-11-15 | — | — | US | disclosed |
| EP-1786812-B1 | PYRIDINE METHYLENE AZOLIDINONES AND THEIR USE AS PHOSPHOINOSITIDE INHIBITORS | MERCK SERONO SA (CH) | 2011-11-09 | — | — | EP | disclosed |
| US-20110034458-A1 | PYRIDINE METHYLENE AZOLIDINONES AND USE THEREOF PHOSPHOINOSITIDE INHIBITORS | APPLIED RESEARCH SYSTEMS ARS HOLDING N.V. (AN) | 2011-02-10 | — | — | US | disclosed |
| US-20110034458-A1 | PYRIDINE METHYLENE AZOLIDINONES AND USE THEREOF PHOSPHOINOSITIDE INHIBITORS | APPLIED RESEARCH SYSTEMS ARS HOLDING N.V. (AN) | 2011-02-10 | — | — | US | disclosed |
| US-7842698-B2 | Pyridine methylene azolidinones and use thereof phosphoinositide inhibitors | MERCK SERONO S.A. (CH) | 2010-11-30 | — | — | US | disclosed |
| US-7842698-B2 | Pyridine methylene azolidinones and use thereof phosphoinositide inhibitors | MERCK SERONO S.A. (CH) | 2010-11-30 | — | — | US | disclosed |
| US-7842698-B2 | Pyridine methylene azolidinones and use thereof phosphoinositide inhibitors | MERCK SERONO S.A. (CH) | 2010-11-30 | — | — | US | disclosed |
| US-20080269227-A1 | Pyridine Methylene Azolidinones and Use Thereof Phosphoinositide Inhibitors | APPLIED RESEARCH SYSTEM ARS HOLDING N.V. (NL) | 2008-10-30 | — | — | US | disclosed |
| US-20080269227-A1 | Pyridine Methylene Azolidinones and Use Thereof Phosphoinositide Inhibitors | APPLIED RESEARCH SYSTEM ARS HOLDING N.V. (NL) | 2008-10-30 | — | — | US | disclosed |
| US-20080269227-A1 | Pyridine Methylene Azolidinones and Use Thereof Phosphoinositide Inhibitors | APPLIED RESEARCH SYSTEM ARS HOLDING N.V. (NL) | 2008-10-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080269227-A1 | Pyridine Methylene Azolidinones and Use Thereof Phosphoinositide Inhibitors | PIK3CD, PIK3CA, PIK3CB | CYP11B2 1495/4885MKNK2 269/4885DYRK1A 3122/4885 |
| US-20110034458-A1 | PYRIDINE METHYLENE AZOLIDINONES AND USE THEREOF PHOSPHOINOSITIDE INHIBITORS | PIK3CD, PIK3CA, PTEN | CYP11B2 1298/4885MKNK2 271/4885DYRK1A 3298/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.