Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 9/20 | 0.46 |
| ▸ | HRH3 | Q9Y5N1 | 8/20 | 0.45 |
| ▸ | TBXAS1 | P24557 | 2/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.35 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.34 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8619886 | 0.83 | HRH4 (0.61) | HRH4HRH3TAAR1 | |
| SCHEMBL8625836 | 0.80 | HRH3 (0.63) | HRH4HRH3TBXAS1TAAR1 | |
| SCHEMBL8621926 | 0.80 | HRH3 (0.60) | HRH4HRH3TAAR1 | |
| SCHEMBL8620794 | 0.79 | HRH3 (0.56) | HRH4HRH3TBXAS1TAAR1 | |
| SCHEMBL8805742 | 0.77 | HRH4 (0.54) | HRH4HRH3LMNATAAR1 | |
| SCHEMBL11660030 | 0.77 | HRH3 (0.43) | HRH4HRH3L3MBTL1LMNASCN5A | |
| SCHEMBL8619999 | 0.76 | HRH4 (0.61) | HRH4HRH3TAAR1 | |
| Iodide SCHEMBL11665504 | 0.75 | HRH4 (0.45) | HRH4HRH3TBXAS1 | |
| SCHEMBL8624871 | 0.75 | HRH4 (0.57) | HRH4HRH3TBXAS1TAAR1 | |
| SCHEMBL8808473 | 0.74 | HRH4 (0.56) | HRH4HRH3TBXAS1TAAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4104382-A | (((THIAZOLYL-, ISOTHIAZOLYL- OR PYRIDYLALKYL)THIO)ALKYL)GUANIDINE | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1978-08-01 | — | — | US | disclosed |
| US-4000302-A | ANTIHISTAMINES | SMITH KLINE & FRENCH LABORATORIES LIMITED (EN) | 1976-12-28 | — | — | US | disclosed |