Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 12/20 | 0.63 |
| ▸ | HRH4 | Q9H3N8 | 12/20 | 0.63 |
| ▸ | NOS1 | P29475 | 1/20 | 0.43 |
| ▸ | HTR3A | P46098 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.42 |
| ▸ | TBXAS1 | P24557 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8619886 | 0.97 | HRH4 (0.61) | HRH3HRH4NOS1HTR3AMEN1 | |
| SCHEMBL8621926 | 0.93 | HRH3 (0.60) | HRH3HRH4NOS1MEN1TP53 | |
| SCHEMBL8620794 | 0.92 | HRH3 (0.56) | HRH3HRH4MEN1TP53CYP1A2 | |
| SCHEMBL8619999 | 0.87 | HRH4 (0.61) | HRH3HRH4TP53CYP1A2CYP3A4 | |
| SCHEMBL8624871 | 0.86 | HRH4 (0.57) | HRH3HRH4TP53CYP1A2CYP3A4 | |
| SCHEMBL8805742 | 0.86 | HRH4 (0.54) | HRH3HRH4NOS1MEN1TP53 | |
| SCHEMBL8805366 | 0.82 | HRH4 (0.63) | HRH3HRH4MEN1TP53CYP1A2 | |
| SCHEMBL8808473 | 0.81 | HRH4 (0.56) | HRH3HRH4MEN1TP53CYP1A2 | |
| Bromide SCHEMBL11657850 | 0.80 | HRH4 (0.46) | HRH3HRH4TAAR1TBXAS1 | |
| SCHEMBL15121693 | 0.78 | TAAR1 (0.65) | HRH3TSHRTAAR1TBXAS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0573542-B1 | IMIDAZOLE-DERIVATIVES HAVING ANTAGONISTIC ACTIVITY ON THE HISTAMINE H3-RECEPTOR | SEED CAPITAL INVESTMENTS (NL) | 1997-10-15 | — | — | EP | claimed |
| EP-0573542-A1 | IMIDAZOLE-DERIVATIVES HAVING AGONISTIC OR ANTAGONISTIC ACTIVITY ON THE HISTAMINE H 3?-RECEPTOR. | SEED CAPITAL INVESTMENTS (NL) | 1993-12-15 | — | — | EP | claimed |
| WO-1992015567-A1 | IMIDAZOLE-DERIVATIVES HAVING AGONISTIC OR ANTAGONISTIC ACTIVITY ON THE HISTAMINE H3-RECEPTOR | SEED CAPITAL INVESTMENT (SCI) B.V. (NL) | 1992-09-17 | — | — | WO | claimed |
| US-5837718-A | ANTIHISTAMINES | SEED CAPITAL INVESTMENT (SCI) B.V. (NL) | 1998-11-17 | — | — | US | disclosed |