Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN1A | P35498 | 7/20 | 0.51 |
| ▸ | SCN5A | Q14524 | 7/20 | 0.51 |
| ▸ | SCN9A | Q15858 | 7/20 | 0.51 |
| ▸ | ADRB2 | P07550 | 9/20 | 0.49 |
| ▸ | ADRB1 | P08588 | 9/20 | 0.49 |
| ▸ | ADRB3 | P13945 | 8/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | NPY1R | P25929 | 1/20 | 0.44 |
| ▸ | NPY2R | P49146 | 1/20 | 0.44 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | HTR1A | P08908 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | HTR2A | P28223 | 1/20 | 0.43 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.43 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | THRB | P10828 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11657132 | 0.87 | SCN5A (0.66) | SCN1ASCN5ASCN9AADRB2ADRB1 | |
| SCHEMBL11659360 | 0.85 | MEN1 (0.61) | SCN1ASCN5ASCN9AADRB2ADRB1 | |
| SCHEMBL11653579 | 0.85 | LMNA (0.62) | SCN1ASCN5ASCN9AADRB2ADRB1 | |
| Fumaric Acid SCHEMBL11659976 | 0.84 | SCN5A (0.59) | SCN1ASCN5ASCN9AADRB2ADRB1 | |
| Fumaric Acid SCHEMBL11659983 | 0.84 | SCN5A (0.59) | SCN1ASCN5ASCN9AADRB2ADRB1 | |
| SCHEMBL11659602 | 0.82 | SCN1A (0.56) | SCN1ASCN5ASCN9AADRB2ADRB1 | |
| Fumaric Acid SCHEMBL11657542 | 0.82 | MEN1 (0.53) | SCN1ASCN5ASCN9AADRB2ADRB1 | |
| Fumaric Acid SCHEMBL11657550 | 0.82 | MEN1 (0.53) | SCN1ASCN5ASCN9AADRB2ADRB1 | |
| SCHEMBL11660135 | 0.81 | SCN5A (0.68) | SCN1ASCN5ASCN9AADRB2ADRB1 | |
| SCHEMBL11659363 | 0.80 | SCN1A (0.53) | SCN1ASCN5ASCN9AADRB2ADRB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4075208-A | HYPOTENSIVE AGENTS | CIBA-GEIGY CORPORATION (US) | 1978-02-21 | — | — | US | disclosed |
| US-4075335-A | HYPOTENSIVE AGENTS | CIBA-GEIGY CORPORATION (US) | 1978-02-21 | — | — | US | disclosed |
| US-3956335-A | HYPERTENSIVE AGENTS | CIBA-GEIGY CORPORATION (US) | 1976-05-11 | — | — | US | disclosed |