Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.62 |
| ▸ | NPY1R | P25929 | 1/20 | 0.62 |
| ▸ | NPY2R | P49146 | 1/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.61 |
| ▸ | MEN1 | O00255 | 3/20 | 0.61 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.55 |
| ▸ | SCN1A | P35498 | 5/20 | 0.53 |
| ▸ | SCN5A | Q14524 | 5/20 | 0.53 |
| ▸ | SCN9A | Q15858 | 5/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | ADRB2 | P07550 | 3/20 | 0.47 |
| ▸ | ADRB1 | P08588 | 3/20 | 0.47 |
| ▸ | ADRB3 | P13945 | 3/20 | 0.47 |
| ▸ | OPRL1 | P41146 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11656717 | 0.94 | LMNA (0.64) | LMNANPY1RNPY2RKMT2AMEN1 | |
| SCHEMBL11657132 | 0.90 | SCN5A (0.66) | LMNANPY1RNPY2RKMT2AMEN1 | |
| SCHEMBL11659360 | 0.88 | MEN1 (0.61) | LMNANPY1RNPY2RKMT2AMEN1 | |
| SCHEMBL11662910 | 0.85 | SCN1A (0.51) | LMNANPY1RNPY2RSCN1ASCN5A | |
| Fumaric Acid SCHEMBL11659983 | 0.84 | SCN5A (0.59) | LMNANPY1RNPY2RALDH1A1SCN1A | |
| Fumaric Acid SCHEMBL11659976 | 0.84 | SCN5A (0.59) | LMNANPY1RNPY2RALDH1A1SCN1A | |
| SCHEMBL11660135 | 0.84 | SCN5A (0.68) | LMNANPY1RNPY2RKMT2AMEN1 | |
| SCHEMBL11659602 | 0.82 | SCN1A (0.56) | LMNANPY1RNPY2RKMT2AMEN1 | |
| Fumaric Acid SCHEMBL11657542 | 0.82 | MEN1 (0.53) | KMT2AMEN1SCN1ASCN5ASCN9A | |
| Fumaric Acid SCHEMBL11657550 | 0.82 | MEN1 (0.53) | KMT2AMEN1SCN1ASCN5ASCN9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4075208-A | HYPOTENSIVE AGENTS | CIBA-GEIGY CORPORATION (US) | 1978-02-21 | — | — | US | claimed |
| US-4075335-A | HYPOTENSIVE AGENTS | CIBA-GEIGY CORPORATION (US) | 1978-02-21 | — | — | US | disclosed |
| US-4075208-A | HYPOTENSIVE AGENTS | CIBA-GEIGY CORPORATION (US) | 1978-02-21 | — | — | US | disclosed |
| US-3956335-A | HYPERTENSIVE AGENTS | CIBA-GEIGY CORPORATION (US) | 1976-05-11 | — | — | US | disclosed |