Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.38 |
| ▸ | PRKAB2 | O43741 | 1/20 | 0.33 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.33 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.33 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.33 |
| ▸ | PRKAG3 | Q9UGI9 | 1/20 | 0.33 |
| ▸ | PRKAG2 | Q9UGJ0 | 1/20 | 0.33 |
| ▸ | PRKAB1 | Q9Y478 | 1/20 | 0.33 |
| ▸ | KCNN3 | Q9UGI6 | 3/20 | 0.32 |
| ▸ | KCNN1 | Q92952 | 1/20 | 0.32 |
| ▸ | KCNN2 | Q9H2S1 | 1/20 | 0.32 |
| ▸ | CDK9 | P50750 | 5/20 | 0.31 |
| ▸ | CDK2 | P24941 | 2/20 | 0.31 |
| ▸ | CDK7 | P50613 | 2/20 | 0.31 |
| ▸ | CDK13 | Q14004 | 1/20 | 0.31 |
| ▸ | CDK12 | Q9NYV4 | 1/20 | 0.31 |
| ▸ | CCNT1 | O60563 | 4/20 | 0.30 |
| ▸ | CDK4 | P11802 | 1/20 | 0.30 |
| ▸ | CCND1 | P24385 | 1/20 | 0.30 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11608751 | 0.71 | PRKAB2 (0.49) | PDE10APRKAB2PRKAG1PRKAA2PRKAA1 | |
| SCHEMBL11606854 | 0.69 | CDK7 (0.50) | PDE10APRKAB2PRKAG1PRKAA2PRKAA1 | |
| SCHEMBL11668245 | 0.69 | CDK2 (0.35) | CDK2CCNA1 | |
| SCHEMBL860641 | 0.68 | PDE10A (0.53) | PDE10AKCNN3KCNN1KCNN2CRHR1 | |
| SCHEMBL7847598 | 0.68 | CDK2 (0.44) | PDE10APRKAB2PRKAG1PRKAA2PRKAA1 | |
| SCHEMBL7830045 | 0.68 | PDE10A (0.53) | PDE10APRKAB2PRKAG1PRKAA2PRKAA1 | |
| SCHEMBL3199721 | 0.67 | PDE10A (0.40) | PDE10AKCNN3KCNN1KCNN2CRHR1 | |
| SCHEMBL11606779 | 0.67 | CDK9 (0.52) | PDE10APRKAB2PRKAG1PRKAA2PRKAA1 | |
| SCHEMBL4196423 | 0.67 | SRD5A1 (0.34) | PDE10ACDK2CCNE1 | |
| SCHEMBL477214 | 0.63 | ERCC5 (0.33) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4093617-A | ENZYME INHIBITORS | ICN PHARMACEUTICALS, INC. (US) | 1978-06-06 | — | — | US | disclosed |