Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB1 | P08588 | 10/20 | 0.73 |
| ▸ | ADRB2 | P07550 | 9/20 | 0.73 |
| ▸ | LMNA | P02545 | 3/20 | 0.73 |
| ▸ | TSHR | P16473 | 3/20 | 0.73 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.73 |
| ▸ | RECQL | P46063 | 1/20 | 0.73 |
| ▸ | ADRB3 | P13945 | 4/20 | 0.55 |
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.55 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.55 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.55 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.55 |
| ▸ | HTR2B | P41595 | 3/20 | 0.55 |
| ▸ | NR2E1 | Q9Y466 | 3/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.55 |
| ▸ | HTR2A | P28223 | 3/20 | 0.55 |
| ▸ | HTR2C | P28335 | 3/20 | 0.55 |
| ▸ | HTR6 | P50406 | 3/20 | 0.55 |
| ▸ | SCN1A | P35498 | 2/20 | 0.55 |
| ▸ | SLC10A1 | Q14973 | 2/20 | 0.55 |
| ▸ | SCN2A | Q99250 | 2/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11669644 | 1.00 | ADRB1 (0.73) | ADRB1ADRB2LMNATSHRADRA1A | |
| SCHEMBL11669093 | 1.00 | ADRB1 (0.73) | ADRB1ADRB2LMNATSHRADRA1A | |
| SCHEMBL11514678 | 1.00 | ADRB1 (0.73) | ADRB1ADRB2LMNATSHRADRA1A | |
| SCHEMBL11669100 | 1.00 | ADRB1 (0.73) | ADRB1ADRB2LMNATSHRADRA1A | |
| SCHEMBL11700816 | 0.90 | ADRB1 (0.60) | ADRB1ADRB2LMNATSHRADRA1A | |
| SCHEMBL13148927 | 0.88 | TSHR (0.76) | ADRB1ADRB2LMNATSHRADRA1A | |
| SCHEMBL11515097 | 0.86 | ADRB1 (0.55) | ADRB1ADRB2LMNATSHRADRA1A | |
| R-Nadolol SCHEMBL4960286 | 0.86 | ADRB2 (0.75) | ADRB1ADRB2LMNATSHRADRA1A | |
| R-Nadolol SCHEMBL3737246 | 0.85 | ADRB2 (0.74) | ADRB1ADRB2LMNATSHRADRA1A | |
| SCHEMBL11511939 | 0.85 | ADRB1 (0.54) | ADRB1ADRB2LMNATSHRADRA1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4029676-A | ANTIADRENERGIC, ANTIFIBRILLATORY | E. R. SQUIBB & SONS, INC. (US) | 1977-06-14 | — | — | US | disclosed |