Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.59 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.59 |
| ▸ | PKM | P14618 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.49 |
| ▸ | MEN1 | O00255 | 5/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.49 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.49 |
| ▸ | GAA | P10253 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | TSHR | P16473 | 2/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.49 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.49 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.49 |
| ▸ | THPO | P40225 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11522544 | 0.94 | MAPT (0.65) | MAPTNPSR1PKMKMT2AMEN1 | |
| SCHEMBL2996737 | 0.88 | MAPT (0.70) | MAPTNPSR1PKMKMT2AMEN1 | |
| SCHEMBL11829270 | 0.84 | CYP2C9 (0.67) | MAPTNPSR1KMT2AMEN1CYP2C9 | |
| SCHEMBL11804731 | 0.84 | MAPT (0.65) | MAPTNPSR1PKMKMT2AMEN1 | |
| SCHEMBL11669240 | 0.83 | CA1 (0.55) | MAPTNPSR1KMT2AMEN1CYP2C9 | |
| SCHEMBL11693805 | 0.82 | ALDH1A1 (0.58) | MAPTNPSR1PKMKMT2AMEN1 | |
| SCHEMBL2991073 | 0.82 | PKM (0.69) | MAPTNPSR1PKMKMT2AMEN1 | |
| SCHEMBL11781375 | 0.81 | MAPT (0.52) | MAPTNPSR1PKMKMT2AMEN1 | |
| SCHEMBL11669776 | 0.81 | ALDH1A1 (0.51) | MAPTNPSR1KMT2AMEN1CYP2C9 | |
| SCHEMBL11829351 | 0.81 | NPSR1 (0.64) | MAPTNPSR1PKMKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-3957998-A | ADMINISTERING | BAYER AKTIENGESELLSCHAFT (DT) | 1976-05-18 | — | — | US | claimed |
| US-4049662-A | HYPOTENSIVE AGENTS, VASODILATORS | BAYER AKTIENGESELLSCHAFT (DT) | 1977-09-20 | — | — | US | disclosed |
| US-4016277-A | ANTIHYPERTENSIVE AGENTS AND CORONARY VESSEL DILATORS | BAYER AKTIENGESELLSCHAFT (DT) | 1977-04-05 | — | — | US | disclosed |
| US-3988458-A | HYPOTENSIVE, CORONARY DILATORS | BAYER AKTIENGESELLSCHAFT (DT) | 1976-10-26 | — | — | US | disclosed |
| US-3959474-A | 2,6-Diamino-1,4-dihydropyridine-3,5-dicarboxylic acid esters used as coronary vessel dilators and anti-hypertensive agents | BAYER AKTIENGESELLSCHAFT (DT) | 1976-05-25 | — | — | US | disclosed |
| US-3957998-A | ADMINISTERING | BAYER AKTIENGESELLSCHAFT (DT) | 1976-05-18 | — | — | US | disclosed |
| US-3950336-A | HYPOTENSIVE AGENTS, CORONARY VESSEL DILATORS | BAYER AKTIENGESELLSCHAFT (DT) | 1976-04-13 | — | — | US | disclosed |