Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.53 |
| ▸ | MAPT | P10636 | 2/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | ACHE | P22303 | 1/20 | 0.50 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.49 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.49 |
| ▸ | TAS2R8 | Q9NYW2 | 3/20 | 0.49 |
| ▸ | MMP1 | P03956 | 4/20 | 0.48 |
| ▸ | MMP2 | P08253 | 4/20 | 0.48 |
| ▸ | MMP9 | P14780 | 4/20 | 0.48 |
| ▸ | HPSE | Q9Y251 | 2/20 | 0.47 |
| ▸ | HPGD | P15428 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1167114 | 1.00 | ALDH1A1 (0.53) | ALDH1A1MAPTLMNAACHEHCRTR1 | |
| SCHEMBL1167236 | 0.90 | HCRTR1 (0.49) | ALDH1A1MAPTLMNAACHEHCRTR1 | |
| SCHEMBL1167328 | 0.90 | HCRTR1 (0.49) | ALDH1A1MAPTLMNAACHEHCRTR1 | |
| SCHEMBL1167238 | 0.90 | HCRTR1 (0.49) | ALDH1A1MAPTLMNAACHEHCRTR1 | |
| SCHEMBL1167286 | 0.89 | TAS2R8 (0.49) | ALDH1A1MAPTLMNAACHEHCRTR1 | |
| SCHEMBL1166231 | 0.89 | TAS2R8 (0.49) | ALDH1A1MAPTLMNAACHEHCRTR1 | |
| SCHEMBL1166233 | 0.89 | TAS2R8 (0.49) | ALDH1A1MAPTLMNAACHEHCRTR1 | |
| SCHEMBL1168047 | 0.88 | HCRTR1 (0.51) | ALDH1A1MAPTLMNAHCRTR1HCRTR2 | |
| SCHEMBL1166590 | 0.88 | HCRTR1 (0.51) | ALDH1A1MAPTLMNAHCRTR1HCRTR2 | |
| SCHEMBL1166588 | 0.88 | HCRTR1 (0.51) | ALDH1A1MAPTLMNAHCRTR1HCRTR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2242743-B1 | AMINOPYRAZOLE DERIVATIVES | ACTELION PHARMACEUTICALS LTD (CH) | 2013-08-21 | — | — | EP | disclosed |
| US-8288419-B2 | Aminopyrazole derivatives | ACTELION PHARMACEUTICALS, LTD (CH) | 2012-10-16 | — | — | US | disclosed |
| US-20110034516-A1 | AMINOPYRAZOLE DERIVATIVES | ACTELION (CH) | 2011-02-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110034516-A1 | AMINOPYRAZOLE DERIVATIVES | CYP3A43, CYP1A2, CYP3A5 | ALDH1A1 96/4885MAPT 2198/4885LMNA 4005/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.