Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.61 |
| ▸ | MAPT | P10636 | 1/20 | 0.61 |
| ▸ | HPGD | P15428 | 1/20 | 0.61 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.61 |
| ▸ | DRD2 | P14416 | 8/20 | 0.54 |
| ▸ | DRD4 | P21917 | 8/20 | 0.54 |
| ▸ | DRD3 | P35462 | 8/20 | 0.54 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | LTA4H | P09960 | 4/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11671812 | 0.95 | ALDH1A1 (0.59) | LMNAALDH1A1MAPTHPGDSMN1; SMN2 | |
| SCHEMBL7451259 | 0.95 | LMNA (0.58) | LMNAALDH1A1MAPTHPGDSMN1; SMN2 | |
| SCHEMBL510500 | 0.86 | ALDH1A1 (0.73) | LMNAALDH1A1MAPTHPGDSMN1; SMN2 | |
| SCHEMBL1470314 | 0.83 | ALDH1A1 (0.60) | LMNAALDH1A1MAPTHPGDSMN1; SMN2 | |
| SCHEMBL1443663 | 0.82 | ALDH1A1 (0.69) | LMNAALDH1A1MAPTHPGDSMN1; SMN2 | |
| SCHEMBL14134159 | 0.82 | ALDH1A1 (0.68) | LMNAALDH1A1MAPTHPGDSMN1; SMN2 | |
| SCHEMBL541949 | 0.82 | ALDH1A1 (0.68) | LMNAALDH1A1MAPTHPGDSMN1; SMN2 | |
| SCHEMBL7405331 | 0.81 | HTR1B (0.58) | LMNAALDH1A1MAPTHPGDSMN1; SMN2 | |
| SCHEMBL1239921 | 0.81 | ALDH1A1 (0.67) | LMNAALDH1A1MAPTHPGDSMN1; SMN2 | |
| SCHEMBL585375 | 0.81 | ALDH1A1 (0.67) | LMNAALDH1A1MAPTHPGDSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4053514-A | ANTIDEPRESSANTS | E. R. SQUIBB & SONS, INC. (US) | 1977-10-11 | — | — | US | disclosed |
| US-4038274-A | ANTIDEPRESSANTS | E. R. SQUIBB & SONS, INC. (US) | 1977-07-26 | — | — | US | disclosed |
| US-3969527-A | INDENO(1,2-C)PYRAZOLE | E. R. SQUIBB & SONS, INC. (US) | 1976-07-13 | — | — | US | disclosed |