Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLCG1 | P19174 | 1/20 | 0.67 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 5/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.43 |
| ▸ | MAPT | P10636 | 4/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | CTDSP1 | Q9GZU7 | 2/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.43 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.43 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.43 |
| ▸ | SLC15A2 | Q16348 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8664795 | 0.90 | PLCG1 (0.81) | PLCG1ALDH1A1L3MBTL1TDP1KDM4E | |
| SCHEMBL11512916 | 0.90 | PLCG1 (0.81) | PLCG1ALDH1A1L3MBTL1TDP1KDM4E | |
| SCHEMBL8664798 | 0.90 | PLCG1 (0.81) | PLCG1ALDH1A1L3MBTL1TDP1KDM4E | |
| SCHEMBL8664695 | 0.87 | PLCG1 (0.67) | PLCG1ALDH1A1L3MBTL1TDP1KDM4E | |
| SCHEMBL8664694 | 0.87 | PLCG1 (0.67) | PLCG1ALDH1A1L3MBTL1TDP1KDM4E | |
| SCHEMBL10790176 | 0.87 | PLCG1 (0.66) | PLCG1ALDH1A1L3MBTL1TDP1KDM4E | |
| SCHEMBL10790178 | 0.87 | PLCG1 (0.66) | PLCG1ALDH1A1L3MBTL1TDP1KDM4E | |
| SCHEMBL10983253 | 0.87 | PLCG1 (0.58) | PLCG1ALDH1A1L3MBTL1TDP1KDM4E | |
| SCHEMBL11675068 | 0.86 | PLCG1 (0.64) | PLCG1ALDH1A1L3MBTL1TDP1KDM4E | |
| SCHEMBL11674640 | 0.86 | PLCG1 (0.62) | PLCG1ALDH1A1L3MBTL1TDP1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4065621-A | Process for 3-alkyl and 3-phenyl cephalosporins | ELI LILLY AND COMPANY (US) | 1977-12-27 | — | — | US | disclosed |
| US-4065618-A | Process for 3-H-3-cephem esters | ELI LILLY AND COMPANY (US) | 1977-12-27 | — | — | US | disclosed |
| US-4013651-A | 3-SUBSTITUTED AMINO-CEPHALOSPORINS | ELI LILLY AND COMPANY (US) | 1977-03-22 | — | — | US | disclosed |
| US-3992377-A | 3-Thio-substituted cephalosporin antibiotics | ELI LILLY AND COMPANY (US) | 1976-11-16 | — | — | US | disclosed |