Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR1 | P21554 | 1/20 | 0.33 |
| ▸ | CNR2 | P34972 | 1/20 | 0.33 |
| ▸ | THRA | P10827 | 1/20 | 0.31 |
| ▸ | THRB | P10828 | 1/20 | 0.31 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL11678255 | 0.87 | THRB (0.30) | THRB | |
| SCHEMBL11680487 | 0.82 | CNR2 (0.39) | CNR1CNR2THRATHRBPSMB5 | |
| Hydrochloric Acid SCHEMBL11677294 | 0.82 | CNR2 (0.39) | CNR1CNR2THRATHRBPSMB5 | |
| SCHEMBL11677724 | 0.80 | CNR2 (0.38) | CNR1CNR2 | |
| Hydrochloric Acid SCHEMBL11678033 | 0.75 | CNR2 (0.39) | CNR1CNR2 | |
| Hydrochloric Acid SCHEMBL11680599 | 0.75 | CNR2 (0.41) | CNR1CNR2 | |
| Hydrochloric Acid SCHEMBL11678139 | 0.75 | CNR1 (0.33) | CNR1CNR2 | |
| Hydrochloric Acid SCHEMBL11678716 | 0.74 | CNR2 (0.38) | CNR1CNR2 | |
| SCHEMBL11677771 | 0.73 | CNR2 (0.39) | CNR1CNR2THRATHRB | |
| SCHEMBL11680669 | 0.73 | CNR2 (0.40) | CNR1CNR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4020163-A | Use of heterocyclic esters of 5H-[1]benzopyrano [3,4-b]pyridines as analgesics | SHARPS ASSOCIATES (US) | 1977-04-26 | — | — | US | disclosed |