Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.51 |
| ▸ | PTGS2 | P35354 | 5/20 | 0.48 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.48 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.48 |
| ▸ | AKR1C2 | P52895 | 2/20 | 0.48 |
| ▸ | TSHR | P16473 | 2/20 | 0.48 |
| ▸ | CDC42 | P60953 | 1/20 | 0.48 |
| ▸ | RAC1 | P63000 | 1/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | METAP1 | P53582 | 1/20 | 0.46 |
| ▸ | APP | P05067 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11682544 | 0.87 | AKR1C3 (0.64) | TDP1L3MBTL1PTGS2PTGS1AKR1C3 | |
| SCHEMBL11682946 | 0.83 | RAB9A (0.44) | TDP1L3MBTL1PTGS2PTGS1MAPT | |
| SCHEMBL8754690 | 0.79 | TDP1 (0.77) | TDP1L3MBTL1PTGS2PTGS1AKR1C3 | |
| SCHEMBL505811 | 0.79 | TDP1 (0.77) | TDP1L3MBTL1PTGS2PTGS1AKR1C3 | |
| SCHEMBL29508603 | 0.79 | TDP1 (0.77) | TDP1L3MBTL1PTGS2PTGS1AKR1C3 | |
| SCHEMBL505819 | 0.79 | TDP1 (0.77) | TDP1L3MBTL1PTGS2PTGS1AKR1C3 | |
| SCHEMBL29403959 | 0.79 | TDP1 (0.77) | TDP1L3MBTL1PTGS2PTGS1AKR1C3 | |
| SCHEMBL505799 | 0.79 | TDP1 (0.77) | TDP1L3MBTL1PTGS2PTGS1AKR1C3 | |
| SCHEMBL11681428 | 0.79 | TLR9 (0.51) | AKR1C3AKR1C2MAPTLMNA | |
| SCHEMBL4007061 | 0.77 | MEN1 (0.54) | TDP1L3MBTL1PTGS2PTGS1AKR1C3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4052436-A | ANTIINFLAMMATORY | E. R. SQUIBB & SONS, INC. (US) | 1977-10-04 | — | — | US | disclosed |
| US-3989841-A | ANTIINFLAMMATORY | E. R. SQUIBB & SONS, INC. (US) | 1976-11-02 | — | — | US | disclosed |