Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.96 |
| ▸ | FBP1 | P09467 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 2/20 | 0.42 |
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.41 |
| ▸ | HPGD | P15428 | 4/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | GFER | P55789 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12949443 | 0.77 | SMN1; SMN2 (0.59) | SMN1; SMN2GAAALDH1A1HPGDMAPT | |
| SCHEMBL31715322 | 0.75 | SMN1; SMN2 (0.62) | SMN1; SMN2FBP1ALDH1A1HPGDATM | |
| SCHEMBL11723394 | 0.73 | SMN1; SMN2 (0.54) | SMN1; SMN2ALDH1A1HPGDMAPTHTT | |
| SCHEMBL30106080 | 0.72 | SMN1; SMN2 (0.57) | SMN1; SMN2FBP1ALDH1A1HPGDMAPT | |
| SCHEMBL30905076 | 0.72 | SMN1; SMN2 (0.57) | SMN1; SMN2FBP1POLBALDH1A1HPGD | |
| SCHEMBL173265 | 0.67 | FBP1 (1.00) | SMN1; SMN2FBP1GAAALDH1A1MEN1 | |
| SCHEMBL23122641 | 0.66 | KDM4E (0.46) | SMN1; SMN2GAAALDH1A1HPGDMAPT | |
| SCHEMBL7797253 | 0.65 | TXN (0.51) | SMN1; SMN2FBP1 | |
| SCHEMBL295296 | 0.65 | GAA (0.46) | SMN1; SMN2POLBGAAALDH1A1HPGD | |
| SCHEMBL11669798 | 0.65 | GAA (0.46) | SMN1; SMN2POLBGAAALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2316834-A1 | Thiadiazoles or oxadiazoles and their use as inhibitors of JAK protein kinase | Vertex Pharmaceuticals Incorporated (US) | 2011-05-04 | — | — | EP | disclosed |
| US-7271179-B2 | Inhibitors of JAK protein kinase | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2007-09-18 | — | — | US | disclosed |
| US-7271179-B2 | Inhibitors of JAK protein kinase | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2007-09-18 | — | — | US | disclosed |
| US-4001203-A | Heavy metal complexes of azo dyestuffs containing a heterocyclic diazo component and the residue of 5-halogeno-2,3-dihydrozypyridine as coupling component | CIBA-GEIGY AG (CH) | 1977-01-04 | — | — | US | disclosed |