TXN — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
SCHEMBL7797253	0.51	6/20
Benzo[D]Thiazole (SCHEMBL677834)	0.52	3/20
SCHEMBL159798	0.72	2/20
SCHEMBL3688773	0.70	2/20
SCHEMBL1119596	0.68	2/20
SCHEMBL1604294	0.68	2/20
SCHEMBL1605263	0.68	2/20
SCHEMBL175640	0.65	2/20
SCHEMBL10352132	0.63	2/20
SCHEMBL374735	0.62	2/20
SCHEMBL3792726	0.61	2/20
SCHEMBL111843	0.61	2/20
Hydrochloric Acid (SCHEMBL9066571)	0.61	2/20
SCHEMBL7287893	0.58	2/20
SCHEMBL7349410	0.58	2/20
SCHEMBL846351	0.58	2/20
SCHEMBL1451877	0.58	2/20
SCHEMBL6746125	0.58	2/20
SCHEMBL8077898	0.58	2/20
SCHEMBL9399224	0.58	2/20

Clinical trials — most relevant to TXN by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Cysteine Supplementation in Critically Ill Neonates	PHASE2/PHASE3	UNKNOWN
Role of Vitamin E in Gaucher Disease Patients	PHASE3	COMPLETED
Cardioprotective Effects of Melatonin in Patients With Cardiomyopathy	PHASE3	RECRUITING
Verapamil for Beta Cell Survival Therapy in Type 1 Diabetes	PHASE2	COMPLETED
Steroid, Thiamine and Ascorbic Acid for Comatose Out-of-hospital Cardiac Arrest Survivors	PHASE2	COMPLETED
A Proof-of-concept Trial to EvaluAte the efficaCy and Safety Of Cell Therapy TRX103 in Patients With Active, Non-infectious Uveitis	PHASE1	NOT_YET_RECRUITING
A Safety and Pharmacokinetic Study of TRX-818 Administered Orally to Patients With Advanced Cancer	PHASE1	COMPLETED
A Clinical Study Aiming to Assess Pharmacokinetics, Pharmacodynamics and Preliminary Efficacy of TRX-100 in Healthy Volunteers	PHASE1	COMPLETED
The Effects of a Glutathione Precursor (FT061452),on Serum and Intracellular Glutathione Levels	PHASE1	COMPLETED
Impact of Nrf2 Activation on Macrovascular, Microvascular & Leg Function & Walking Capacity in Peripheral Artery Disease	EARLY_PHASE1	RECRUITING
Antioxidant Signature in Adult Patients With Phenylketonuria	nan	COMPLETED
Thiol/Disulphide Homeostasis in Unexplained Infertility	nan	COMPLETED
Macrophage Migration Inhibitory Factor (MIF)- Cardiac Surgery	nan	COMPLETED
Effects of Preoperative Oral Carbohydrate Loading on Maternal Thiol-disulfide Homeostasis	nan	COMPLETED
Evaluation of Mitochondrial Enzyme Activity in Cesarean Section Patients	nan	UNKNOWN
External Nitric Oxide Measurement Through SNO Degradation	nan	ENROLLING_BY_INVITATION
Correlation Research of Thioredoxin Reductase in Lung Cancer	nan	COMPLETED
Effect of Sulfur Amino Acid Depletion and Acetaminophen on Plasma Glutatione	nan	COMPLETED
Characterization of the Nrf2 Response in Patients With Autosomal Dominant Polycystic Kidney Disease (ADPKD)	nan	RECRUITING
Evaluation of the Predictive Effect of Inflammatory Markers in MI Patients	nan	UNKNOWN
Effects of TIVA and Inhalation Anesthesia on Oxidative Stress Factors During Hypotensive Anesthesia	nan	COMPLETED
Effect of Thiol-Disulfide Homeostasis and Ischemia-Modified Albumin Levels on IVF Results in Male Factor Infertility	nan	COMPLETED
Cell Signaling and Resistance to Oxidative Stress: Effects of Aging and Exercise	nan	COMPLETED
The Effects of Dexmedetomidine on Thiol/Disulphide Homeostasis in Coronary Bypass Surgery	nan	UNKNOWN
The Effects of TAP Block on Thiol/Disulfide Homeostasis and Pain in Laparoscopic Gynecological Surgery	nan	COMPLETED
Human Study of Hydroxytyrosol on Phase II Enzymes in Healthy Subjects	nan	COMPLETED
Treatment Strategy to Enhance Nrf2 Signaling in Older Adults	nan	COMPLETED
Saturation Targets and Resuscitation in Preterm Trial	nan	COMPLETED
Mild Intermittent Hypoxia and Its Multipronged Effect on Sleep Apnea	nan	RECRUITING
Reactive Oxygen Species Following Aortic Valve Replacement	nan	COMPLETED

Related proteins — ESM-2 sequence neighbours (a TXN binder may also engage these)

Protein	Name	Similarity
O97680	—	1.000	O97680 →
Q9BDJ3	—	1.000	Q9BDJ3 →
P29451	—	1.000	P29451 →
P82460	—	1.000	P82460 →
P10639	—	1.000	P10639 →
O97508	—	1.000	O97508 →
P11232	—	1.000	P11232 →
P08628	—	0.999	P08628 →
P50413	—	0.995	P50413 →
Q5R9M3	—	0.991	Q5R9M3 →
P08629	—	0.988	P08629 →
Q98TX1	—	0.987	Q98TX1 →
Q9DGI3	—	0.981	Q9DGI3 →
O14463	—	0.961	O14463 →
Q6XHI1	—	0.960	Q6XHI1 →
P29429	—	0.954	P29429 →
Q9V429	—	0.953	Q9V429 →
Q1RQJ0	—	0.953	Q1RQJ0 →
P80028	—	0.952	P80028 →
Q0D840	—	0.951	Q0D840 →
O96952	—	0.950	O96952 →
Q39239	—	0.949	Q39239 →
P29448	—	0.949	P29448 →
A2YIW7	—	0.947	A2YIW7 →
Q1RQI9	—	0.947	Q1RQI9 →
Q42403	—	0.946	Q42403 →
P22803	—	0.945	P22803 →
Q39241	—	0.943	Q39241 →
Q9FNE2	—	0.943	Q9FNE2 →
Q7KQL8	—	0.943	Q7KQL8 →