Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM6B | O15054 | 1/20 | 0.47 |
| ▸ | KDM6A | O15550 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.46 |
| ▸ | MAPT | P10636 | 5/20 | 0.46 |
| ▸ | HPGD | P15428 | 4/20 | 0.46 |
| ▸ | USP2 | O75604 | 2/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.46 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.44 |
| ▸ | NPC1 | O15118 | 5/20 | 0.44 |
| ▸ | RAB9A | P51151 | 5/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.44 |
| ▸ | TP53 | P04637 | 2/20 | 0.44 |
| ▸ | GAA | P10253 | 2/20 | 0.44 |
| ▸ | GLA | P06280 | 1/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | CASP1 | P29466 | 1/20 | 0.44 |
| ▸ | CASP7 | P55210 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12263220 | 0.89 | ALDH1A1 (0.48) | KDM6BKDM6AKDM4EALDH1A1MAPT | |
| SCHEMBL11698999 | 0.87 | KDM4E (0.46) | KDM6BKDM6AKDM4EALDH1A1MAPT | |
| SCHEMBL11699619 | 0.86 | KDM6B (0.44) | KDM6BKDM6AKDM4EALDH1A1MAPT | |
| SCHEMBL11695908 | 0.85 | AKR1C3 (0.59) | MAPTHPGDPTGS2AKR1C3AKR1C2 | |
| SCHEMBL11696447 | 0.84 | KDM4E (0.43) | KDM6BKDM6AKDM4EALDH1A1MAPT | |
| SCHEMBL11701857 | 0.82 | AKR1C3 (0.45) | KDM6BKDM6AKDM4EALDH1A1MAPT | |
| SCHEMBL11701291 | 0.81 | PTGS1 (0.45) | KDM4EALDH1A1MAPTHPGDUSP2 | |
| SCHEMBL11696610 | 0.79 | HPGD (0.55) | KDM6BKDM6AKDM4EALDH1A1MAPT | |
| SCHEMBL7573904 | 0.79 | KDM4E (0.51) | KDM6BKDM6AKDM4EALDH1A1MAPT | |
| SCHEMBL11699642 | 0.78 | AKR1C3 (0.41) | KDM4EALDH1A1MAPTHPGDUSP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4046905-A | Anti-inflammatory, analgesic and antipyretic phenylacetic acids | MERCK & CO., INC. (US) | 1977-09-06 | — | — | US | disclosed |
| US-3947582-A | Phenylacetic acid compounds in treating abnormal platelet aggregation | MERCK & CO., INC. (US) | 1976-03-30 | — | — | US | disclosed |