Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 5/20 | 0.63 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.63 |
| ▸ | TSHR | P16473 | 3/20 | 0.50 |
| ▸ | SLC5A2 | P31639 | 5/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 3/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | IDO1 | P14902 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.40 |
| ▸ | HCRTR2 | O43614 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1170132 | 0.83 | LMNA (0.71) | LMNASMN1; SMN2TSHRSLC5A2ALDH1A1 | |
| SCHEMBL1170704 | 0.79 | LMNA (0.59) | LMNASMN1; SMN2TSHRSLC5A2ALDH1A1 | |
| SCHEMBL1170484 | 0.78 | LMNA (1.00) | LMNASMN1; SMN2TSHRSLC5A2ALDH1A1 | |
| SCHEMBL1170639 | 0.73 | SLC5A2 (0.78) | LMNASMN1; SMN2TSHRSLC5A2ALDH1A1 | |
| SCHEMBL11716491 | 0.71 | LMNA (0.70) | LMNASMN1; SMN2TSHRSLC5A2ALDH1A1 | |
| SCHEMBL1170253 | 0.71 | LMNA (0.65) | LMNASMN1; SMN2TSHRSLC5A2ALDH1A1 | |
| SCHEMBL1169947 | 0.71 | LMNA (0.59) | LMNASMN1; SMN2TSHRSLC5A2ALDH1A1 | |
| SCHEMBL23241374 | 0.71 | LMNA (0.54) | LMNASMN1; SMN2TSHRSLC5A2ALDH1A1 | |
| SCHEMBL10353130 | 0.70 | HTT (0.54) | LMNASMN1; SMN2TSHRALDH1A1HTT | |
| SCHEMBL2475227 | 0.69 | LMNA (0.79) | LMNASMN1; SMN2TSHRSLC5A2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7842817-B2 | 2-amino benzimidazole derivatives and their use as modulators of small-conductance calcium-activated potassium channels | NEUROSEARCH A/S (DK) | 2010-11-30 | — | — | US | claimed |
| EP-1838306-B1 | NOVEL 2-AMINO BENZIMIDAZOLE DERIVATIVES AND THEIR USE AS MODULATORS OF SMALL-CONDUCTANCE CALCIUM-ACTIVATED POTASSIUM CHANNELS | NEUROSEARCH AS (DK) | 2010-11-17 | — | — | EP | claimed |
| US-20080200529-A1 | Novel 2-Amino Benzimidazole Derivatives and Their Use As Modulators Of Small-Conductance Calcium-Activated Potassium Channels | NEURO SEARCH A/S (DK) | 2008-08-21 | — | — | US | claimed |
| EP-2319512-A1 | Novel 2-amino benzimidazole derivatives and their use as modulators of small-conductance calcium-activated potassium channels. | NeuroSearch AS (DK) | 2011-05-11 | — | — | EP | disclosed |
| US-20110034527-A1 | NOVEL 2-AMINO BENZIMIDAZOLE DERIVATIVES AND THEIR USE AS MODULATORS OF SMALL-CONDUCTANCE CALCIUM-ACTIVATED POTASSIUM CHANNELS | SOERENSEN ULRIK SVANE | 2011-02-10 | — | — | US | disclosed |
| US-7842817-B2 | 2-amino benzimidazole derivatives and their use as modulators of small-conductance calcium-activated potassium channels | NEUROSEARCH A/S (DK) | 2010-11-30 | — | — | US | disclosed |
| EP-1838306-B1 | NOVEL 2-AMINO BENZIMIDAZOLE DERIVATIVES AND THEIR USE AS MODULATORS OF SMALL-CONDUCTANCE CALCIUM-ACTIVATED POTASSIUM CHANNELS | NEUROSEARCH AS (DK) | 2010-11-17 | — | — | EP | disclosed |
| US-20100280087-A1 | NOVEL 2-AMINO BENZIMIDAZOLE DERIVATIVES AND THEIR USE AS MODULATORS OF SMALL-CONDUCTANCE CALCIUM-ACTIVATED POTASSIUM CHANNELS | SOERENSEN ULRIK SVANE | 2010-11-04 | — | — | US | disclosed |
| US-20080200529-A1 | Novel 2-Amino Benzimidazole Derivatives and Their Use As Modulators Of Small-Conductance Calcium-Activated Potassium Channels | NEURO SEARCH A/S (DK) | 2008-08-21 | — | — | US | disclosed |
| EP-1838306-A1 | NOVEL 2-AMINO BENZIMIDAZOLE DERIVATIVES AND THEIR USE AS MODULATORS OF SMALL-CONDUCTANCE CALCIUM-ACTIVATED POTASSIUM CHANNELS | NEUROSEARCH A/S (DK) | 2007-10-03 | — | — | EP | disclosed |
| WO-2006074991-A1 | NOVEL 2-AMINO BENZIMIDAZOLE DERIVATIVES AND THEIR USE AS MODULATORS OF SMALL-CONDUCTANCE CALCIUM-ACTIVATED POTASSIUM CHANNELS | NEUROSEARCH A/S (DK) | 2006-07-20 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110034527-A1 | NOVEL 2-AMINO BENZIMIDAZOLE DERIVATIVES AND THEIR USE AS MODULATORS OF SMALL-CONDUCTANCE CALCIUM-ACTIVATED POTASSIUM CHANNELS | KCNN2, KCNN1, KCNN3 | LMNA 2521/4885SMN1; SMN2 2965/4885TSHR 4590/4885 |
| US-20080200529-A1 | Novel 2-Amino Benzimidazole Derivatives and Their Use As Modulators Of Small-Conductance Calcium-Activated Potassium Channels | KCNN2, KCNN1, KCNN3 | LMNA 2521/4885SMN1; SMN2 2965/4885TSHR 4590/4885 |
| US-20100280087-A1 | NOVEL 2-AMINO BENZIMIDAZOLE DERIVATIVES AND THEIR USE AS MODULATORS OF SMALL-CONDUCTANCE CALCIUM-ACTIVATED POTASSIUM CHANNELS | KCNN2, KCNN1, KCNN3 | LMNA 2521/4885SMN1; SMN2 2965/4885TSHR 4590/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.